Development and validation of a nomogram for predicting deep venous thrombosis in patients with pelvic and acetabular fractures: a retrospective cohort study

被引:8
作者
Yang, Zongyou [1 ,2 ,3 ]
Ren, Rongqing [1 ]
Yang, Zhizhou [1 ]
Yang, Hucheng [1 ]
Yin, Yingchao [1 ,2 ,3 ]
Tian, Siyu [1 ,2 ,3 ]
Wang, Zhihong [1 ,2 ,3 ]
Hou, Zhiyong [1 ,2 ,3 ]
机构
[1] Hebei Med Univ, Dept Orthopaed Surg, Hosp 3, 139 Zi Qiang Rd, Shijiazhuang 050051, Hebei, Peoples R China
[2] Orthopaed Res Inst Hebei Prov, Shijiazhuang, Hebei, Peoples R China
[3] Hebei Med Univ, Key Lab Intelligent Orthopaed Equipment, Natl Hlth Commiss NHC, Hosp 3, Shijiazhuang, Hebei, Peoples R China
关键词
Venous thrombosis; Pelvis; Acetabula; Fractures; Risk factors; Nomograms; THROMBOEMBOLISM; MULTICENTER; OBESITY; TRAUMA; RISK;
D O I
10.1186/s12891-023-06879-9
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Purpose To construct a novel nomogram model that can predict DVT and avoid unnecessary examination. Methods Patients admitted to the hospital with pelvis/acetabular fractures were included between July 2014 and July 2018. The potential predictors associated with DVT were analyzed using Univariate and multivariable logistic regression analysis. The predictive nomogram was constructed and internally validated. Results 230 patients were finally enrolled. There were 149 individuals in the non-DVT group and 81 in the DVT group. Following analysis, we obtained the final nomogram model. The risk factors included age (OR, 1.037; 95% CI, 1.013-1.062; P = 0.002), body mass index (BMI) (OR, 1.253; 95% CI, 1.120-1.403; P < 0.001); instant application of anticoagulant after admission (IAA) (OR, 2.734; 95% CI, 0.847-8.829; P = 0.093), hemoglobin (HGB) (OR, 0.970; 95% CI, 0.954-0.986; P < 0.001), D-Dimer(OR, 1.154; 95% CI, 1.016-1.310; P = 0.027) and fibrinogen (FIB) (OR, 1.286; 95% CI, 1.024-1.616; P = 0.002). The apparent C-statistic was 0.811, and the adjusted C-statistic was 0.777 after internal validations, demonstrating good discrimination. Hosmer and Lemeshow's goodness of fit (GOF) test of the predictive model showed a good calibration for the probability of prediction and observation (chi(2) = 3.285, P = 0.915; P > 0.05). The decision curve analysis (DCA) and Clinical impact plot (CIC) demonstrated superior clinical use of the nomogram. Conclusions An easy-to-calculate nomogram model for predicting DVT in patients with pelvic-acetabular fractures were developed. It could help clinicians to reduce DVT and avoid unnecessary examinations.
引用
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页数:8
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