Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies

被引：15
作者：
Joshi, Hemant [1 ]
Gupta, Dhruv Sanjay [2 ]
Kaur, Ginpreet [2 ]
Singh, Tejveer [3 ]
Ramniwas, Seema [4 ]
Sak, Katrin [5 ]
Aggarwal, Diwakar [6 ]
Chhabra, Raunak Singh [7 ]
Gupta, Madhu [8 ]
Saini, Adesh K. [6 ,9 ]
Tuli, Hardeep Singh [6 ]
机构：
[1] Jawaharlal Nehru Univ, Sch Biotechnol, New Delhi 110067, India
[2] SVKMS NMIMS, Shobhaben Pratapbhai Patel Sch Pharm & Technol Man, Dept Pharmacol, Mumbai 400056, India
[3] Delhi Univ, Hansraj Coll, Dept Zool, Translat Oncol Lab, New Delhi 110007, India
[4] Chandigarh Univ, Univ Inst Pharmaceut Sci, Univ Ctr Res & Dev, , Gharuan, Mohali 140413, India
[5] NGO Praeventio, Tartu, Estonia
[6] Maharishi Markandeshwar Deemed Univ, Maharishi Markandeshwar Engn Coll, Dept Biosci & Technol, Ambala 133207, India
[7] Tech Mahindra, Mumbai 400072, Maharashtra, India
[8] Delhi Pharmaceut Sci & Res Univ, Sch Pharmaceut Sci, Dept Pharmaceut, New Delhi 110017, India
[9] Maharishi Markandeshwar Deemed Univ, Fac Agr, Ambala 133207, India
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2023年 / 396卷 / 12期
关键词：
Quercetin; Chemistry; Bioavailability; Chemoprevention; Nanoformulations; Drug delivery; OXIDE NANOPARTICLES; POLYMERIC MICELLES; TUMOR-GROWTH; CANCER; BREAST; APOPTOSIS; PHARMACOKINETICS; BIOAVAILABILITY; METASTASIS; OVARIAN;
D O I：
10.1007/s00210-023-02625-z
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
One of the well-studied older molecules, quercetin, is found in large quantities in many fruits and vegetables. Natural anti-oxidant quercetin has demonstrated numerous pharmacological properties in preclinical and clinical research, including anti-inflammatory and anti-cancer effects. Due to its ability to control cell signaling pathways, including NF-& kappa;B, p53, activated protein-1 (AP-1), STAT3, and epidermal growth response-1 (Egr-1), which is essential in the initiation and proliferation of cancer, it has gained a lot of fame as an anticancer molecule. Recent research suggests that using nanoformulations can help quercetin to overcome its hydrophobicity while also enhancing its stability and cellular bioavailability both in vitro and in vivo. The main aim of this review is to focus on the comprehensive insights of several nanoformulations, including liposomes, nano gels, micelles, solid lipid nanoparticles (SLN), polymer nanoparticles, gold nanoparticles, and cyclodextrin complexes, to transport quercetin for application in cancer.
引用
收藏
页码：3443 / 3458
页数：16
相关论文
共 96 条
[1]   Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects [J].
Abadi, Asal Jalal ;
Mirzaei, Sepideh ;
Mahabady, Mahmood Khaksary ;
Hashemi, Farid ;
Zabolian, Amirhossein ;
Hashemi, Fardin ;
Raee, Pourya ;
Aghamiri, Shahin ;
Ashrafizadeh, Milad ;
Aref, Amir Reza ;
Hamblin, Michael R. ;
Hushmandi, Kiavash ;
Zarrabi, Ali ;
Sethi, Gautam .
PHYTOTHERAPY RESEARCH, 2022, 36 (01) :189-213
[2]   Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements [J].
Aggarwal, Vaishali ;
Tuli, Hardeep S. ;
Thakral, Falak ;
Singhal, Paavan ;
Aggarwal, Diwakar ;
Srivastava, Saumya ;
Pandey, Anjana ;
Sak, Katrin ;
Varol, Mehmet ;
Khan, Md. Asaduzzaman ;
Sethi, Gautam .
EXPERIMENTAL BIOLOGY AND MEDICINE, 2020, 245 (05) :486-497
[3]   Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines [J].
Aghapour, Fahimeh ;
Moghadamnia, Ali Akbar ;
Nicolini, Andrea ;
Kani, Seydeh Narges Mousavi ;
Barari, Ladan ;
Morakabati, Payam ;
Rezazadeh, Leyla ;
Kazemi, Sohrab .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 500 (04) :860-865
[4]   Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways [J].
Almatroodi, Saleh A. ;
Alsahli, Mohammed A. ;
Almatroudi, Ahmad ;
Verma, Amit Kumar ;
Aloliqi, Abdulaziz ;
Allemailem, Khaled S. ;
Khan, Amjad Ali ;
Rahmani, Arshad Husain .
MOLECULES, 2021, 26 (05)
[5]  
Anand David Alexander Victor, 2016, Pharmacogn Rev, V10, P84, DOI 10.4103/0973-7847.194044
[6]   Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets [J].
Asgharian, Parina ;
Tazekand, Abbas Pirpour ;
Hosseini, Kamran ;
Forouhandeh, Haleh ;
Ghasemnejad, Tohid ;
Ranjbar, Maryam ;
Hasan, Muzaffar ;
Kumar, Manoj ;
Beirami, Sohrab Minaei ;
Tarhriz, Vahideh ;
Soofiyani, Saiedeh Razi ;
Kozhamzharova, Latipa ;
Sharifi-Rad, Javad ;
Calina, Daniela ;
Cho, William C. .
CANCER CELL INTERNATIONAL, 2022, 22 (01)
[7]   Synergistic Effect of Quercetin Magnetite Nanoparticles and Targeted Radiotherapy in Treatment of Breast Cancer [J].
Askar, Mostafa A. ;
El-Nashar, Heba A. S. ;
Al-Azzawi, Mahmood A. ;
Rahman, Sahar S. Abdel ;
Elshawi, Omama E. .
BREAST CANCER-BASIC AND CLINICAL RESEARCH, 2022, 16
[8]   In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles [J].
Baksi, Ruma ;
Singh, Devendra Pratap ;
Borse, Swapnil P. ;
Rana, Rita ;
Sharma, Vipin ;
Nivsarkar, Manish .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 106 :1513-1526
[9]   Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231) [J].
Balakrishnan, Solaimuthu ;
Mukherjee, Sudip ;
Das, Sourav ;
Bhat, Firdous Ahmad ;
Singh, Paulraj Raja ;
Patra, Chitta Ranjan ;
Arunakaran, Jagadeesan .
CELL BIOCHEMISTRY AND FUNCTION, 2017, 35 (04) :217-231
[10]   Preparation, characterization, cytotoxicity and pharmacokinetics of niosomes containing gemcitabine: In vitro, in vivo, and simulation studies [J].
Barani, Mahmood ;
Hajinezhad, Mohammad Reza ;
Zargari, Farshid ;
Shahraki, Sheida ;
Davodabadi, Fatemeh ;
Mirinejad, Shekoufeh ;
Sargazi, Saman ;
Rahdar, Abbas ;
Diez-Pascual, Ana M. .
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2023, 84
12345678910