Polyclonal immunoglobulins for COVID-19 pre-exposure prophylaxis in immunocompromised patients

被引：4

作者：

Focosi, Daniele ^{[1
]}

Franchini, Massimo ^{[2
]}

机构：

[1] Pisa Univ Hosp, North Western Tuscany Blood Bank, I-56100 Pisa, Italy

[2] Carlo Poma Hosp, Div Hematol & Transfus Med, I-46100 Mantua, Italy

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2023年 / 62卷 / 03期

关键词：

Polyclonal immunoglobulins; COVID-19;

D O I：

10.1016/j.transci.2023.103648

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunocompromised patients remain at high risk of COVID-19 morbidity and mortality. After recent Omicron sublineages gained full resistance to EvusheldTM, they are left without effective pre-exposure prophylaxis. We review here arguments to support the growing role of regular immunoglobulin (IG) infusions at protecting against COVID-19. Since there is evidence for neutralizing antibody titers approaching the ones seen in hyperimmune sera, and since some categories of patients at risk for COVID-19 progression are already under preexposure prophylaxis with IG, this cost-effective strategy should be urgently investigated in randomized clinical trials. Surveys of anti-Spike antibody levels in current plasma donations are urgent to forecast the potency of future IG batches

引用

页数：5

共 29 条

[1] Severe Acute Respiratory Syndrome Coronavirus 2 Hyperimmune Intravenous Human Immunoglobulins Neutralizes Omicron Subvariants BA.1, BA.2, BA.2.12.1, BA.3, and BA.4/BA.5 for Treatment of Coronavirus Disease 2019 [J].

Awasthi, Mayanka ;

Golding, Hana ;

Khurana, Surender .

CLINICAL INFECTIOUS DISEASES, 2023, 76 (03) :E503-E506

[2] Anti-SARS-CoV-2 Antibodies Within IVIg Preparations: Cross-Reactivities With Seasonal Coronaviruses, Natural Autoimmunity, and Therapeutic Implications [J].

Dalakas, Marinos C. ;

Bitzogli, Kleopatra ;

Alexopoulos, Harry .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[3] Currently available intravenous immunoglobulin contains antibodies reacting against severe acute respiratory syndrome coronavirus 2 antigens [J].

Diez, Jose-Maria ;

Romero, Carolina ;

Gajardo, Rodrigo .

IMMUNOTHERAPY, 2020, 12 (08) :571-576

[4] Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization by Intravenous Immunoglobulins Produced From Plasma Collected During the 2020 Pandemic [J].

Farcet, Maria R. ;

Karbiener, Michael ;

Schwaiger, Julia ;

Ilk, Reinhard ;

Kreil, Thomas R. .

JOURNAL OF INFECTIOUS DISEASES, 2021, :1357-1361

[5]

Focosi D., 2020, CLIN MICROBIOL INFEC, VS1198-743X, P30589

[6]

Focosi D, 2022, VIRUSES-BASEL, P14

[7]

Focosi D, 2022, REV MED VIROL, P2341

[8] Discriminating endogenous vaccine-elicited anti-Spike antibody responses from exogenous anti-Spike monoclonal antibodies: The case of Evusheld [J].

Focosi, Daniele ;

Maggi, Fabrizio ;

Shoham, Shmuel ;

Casadevall, Arturo .

JOURNAL OF MEDICAL VIROLOGY, 2023, 95 (01)

[9] The Road towards Polyclonal Anti-SARS-CoV-2 Immunoglobulins (Hyperimmune Serum) for Passive Immunization in COVID-19 [J].

Focosi, Daniele ;

Tuccori, Marco ;

Franchini, Massimo .

LIFE-BASEL, 2021, 11 (02) :1-9

[10] Passive immunization against COVID-19 by anti-SARS-CoV-2 spike IgG in commercially available immunoglobulin preparations in severe antibody deficiency [J].

Hirsiger, Julia R. ;

Weigang, Sebastian ;

Walz, Antje-Christine ;

Fuchs, Jonas ;

Daly, Mary-Louise ;

Eggimann, Stefan ;

Hausmann, Oliver ;

Schwemmle, Martin ;

Kochs, Georg ;

Panning, Marcus ;

Warnatz, Klaus ;

Recher, Mike ;

Berger, Christoph T. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2022, 10 (09) :2452-+

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