An emerging role of inflammasomes in spinal cord injury and spinal cord tumor

被引:14
作者
Chen, Jiansong [1 ]
Shen, Yiguo [1 ]
Shao, Xiaobo [1 ]
Wu, Weiliang [1 ]
机构
[1] Zhejiang Univ Sch Med, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Orthoped Surg, Hangzhou, Peoples R China
关键词
spinal cord injury; spinal cord tumor; inflammasome; caspase-1; immune response; EPITHELIAL-MESENCHYMAL TRANSITION; NLRP3; INFLAMMASOME; MOLECULAR PLATFORM; INDEPENDENT NLRP3; TRAUMATIC BRAIN; STEM-CELLS; ACTIVATION; MECHANISMS; MACROPHAGE; CASPASES;
D O I
10.3389/fimmu.2023.1119591
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Spinal cord injury (SCI) and spinal cord tumor are devastating events causing structural and functional impairment of the spinal cord and resulting in high morbidity and mortality; these lead to a psychological burden and financial pressure on the patient. These spinal cord damages likely disrupt sensory, motor, and autonomic functions. Unfortunately, the optimal treatment of and spinal cord tumors is limited, and the molecular mechanisms underlying these disorders are unclear. The role of the inflammasome in neuroinflammation in diverse diseases is becoming increasingly important. The inflammasome is an intracellular multiprotein complex and participates in the activation of caspase-1 and the secretion of pro-inflammatory cytokines such as interleukin (IL)-1 beta and IL-18. The inflammasome in the spinal cord is involved in the stimulation of immune-inflammatory responses through the release of pro-inflammatory cytokines, thereby mediating further spinal cord damage. In this review, we highlight the role of inflammasomes in SCI and spinal cord tumors. Targeting inflammasomes is a promising therapeutic strategy for the treatment of SCI and spinal cord tumors.
引用
收藏
页数:12
相关论文
共 133 条
[51]   IL-1β mediated up-regulation of HIF-1α via an NFkB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis [J].
Jung, YJ ;
Isaacs, JS ;
Lee, SM ;
Trepel, J ;
Neckers, L .
FASEB JOURNAL, 2003, 17 (12) :2115-+
[52]   Inflammasomes and Cancer [J].
Karki, Rajendra ;
Man, Si Ming ;
Kanneganti, Thirumala-Devi .
CANCER IMMUNOLOGY RESEARCH, 2017, 5 (02) :94-99
[53]   The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation [J].
Kelley, Nathan ;
Jeltema, Devon ;
Duan, Yanhui ;
He, Yuan .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (13)
[54]   Mechanisms governing inflammasome activation, assembly and pyroptosis induction [J].
Kesavardhana, Sannula ;
Kanneganti, Thirumala-Devi .
INTERNATIONAL IMMUNOLOGY, 2017, 29 (05) :201-210
[55]  
Ketelut-Carneiro N, 2020, CURR BIOL, V30, pR689, DOI 10.1016/j.cub.2020.04.065
[56]   AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice [J].
Kim, Hyunha ;
Seo, Ji Seon ;
Lee, Seo-Yeon ;
Ha, Ki-Tae ;
Choi, Byung Tae ;
Shin, Yong-Il ;
Yun, Young Ju ;
Shin, Hwa Kyoung .
BRAIN BEHAVIOR AND IMMUNITY, 2020, 87 :765-776
[57]   IL-33/ST2 Axis in Organ Fibrosis [J].
Kotsiou, Ourania S. ;
Gourgoulianis, Konstantinos I. ;
Zarogiannis, Sotirios G. .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[58]   XIAP mediates NOD signaling via interaction with RIP2 [J].
Krieg, Andreas ;
Correa, Ricardo G. ;
Garrison, Jason B. ;
Le Negrate, Gaelle ;
Welsh, Kate ;
Huang, Ziwei ;
Knoefel, Wolfram T. ;
Reed, John C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (34) :14524-14529
[59]   Tumor Necrosis Factor (TNF)-α-Stimulated Gene 6 (TSG-6): A Promising Immunomodulatory Target in Acute Neurodegenerative Diseases [J].
La Russa, Daniele ;
Di Santo, Chiara ;
Lizasoain, Ignacio ;
Moraga, Ana ;
Bagetta, Giacinto ;
Amantea, Diana .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (02)
[60]   Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review [J].
Lawton, Andrew J. ;
Lee, Kathleen A. ;
Cheville, Andrea L. ;
Ferrone, Marco L. ;
Rades, Dirk ;
Balboni, Tracy A. ;
Abrahm, Janet L. .
JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (01) :61-+