Role and Recent Advancements of Ionic Liquids in Drug Delivery Systems

被引:40
作者
Shukla, Monu Kumar [1 ]
Tiwari, Harshita [2 ]
Verma, Rachna [3 ]
Dong, Wen-Liang [4 ]
Azizov, Shavkatjon [5 ,6 ]
Kumar, Brajesh [7 ]
Pandey, Sadanand [8 ]
Kumar, Deepak [1 ]
机构
[1] Shoolini Univ, Sch Pharmaceut Sci, Dept Pharmaceut Chem, Solan 173229, India
[2] CSIR Indian Inst Integrat Med, Nat Prod & Med Chem Div, Discovery Informat Lab, Jammu 180001, India
[3] Shoolini Univ, Dept Basic Sci, Solan 173229, India
[4] Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan 250355, Peoples R China
[5] Acad Sci Uzbek, Inst Bioorgan Chem, Lab Biol Act Macromol Syst, Tashkent 100125, Uzbekistan
[6] Tashkent Pharmaceut Inst, Dept Pharmaceut Chem, Tashkent 100015, Uzbekistan
[7] Kolhan Univ, TATA Coll, Dept Chem, Chaibasa 833202, India
[8] Yeungnam Univ, Coll Nat Sci, Dept Chem, Gyongsan 38541, South Korea
关键词
drug delivery systems; ionic liquids; water solubility; biological macromolecules; biomedical applications; WATER-SOLUBLE DRUGS; COUNTERION STRUCTURE; SOLVENTS; BIOAVAILABILITY; SOLUBILITY; SEPARATION; IBUPROFEN; PARAMETER; TOXICITY; COMPLEX;
D O I
10.3390/pharmaceutics15020702
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Advancements in the fields of ionic liquids (ILs) broaden its applications not only in traditional use but also in different pharmaceutical and biomedical fields. Ionic liquids "Solutions for Your Success" have received a lot of interest from scientists due to a myriad of applications in the pharmaceutical industry for drug delivery systems as well as targeting different diseases. Solubility is a critical physicochemical property that determines the drug's fate at the target site. Many promising drug candidates fail in various phases of drug research due to poor solubility. In this context, ionic liquids are regarded as effective drug delivery systems for poorly soluble medicines. ILs are also able to combine different anions/cations with other cations/anions to produce salts that satisfy the concept behind the ILs. The important characteristics of ionic liquids are the modularity of their physicochemical properties depending on the application. The review highlights the recent advancement and further applications of ionic liquids to deliver drugs in the pharmaceutical and biomedical fields.
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页数:18
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