Validation study of the JS']JSHBPS nomogram for patients with colorectal liver metastases who underwent hepatic resection in the recent era - a nationwide survey in Japan

被引：8

作者：

Beppu, Toru ^{[1
]}

Yamamura, Kensuke ^{[1
]}

Sakamoto, Katsunori ^{[2
]}

Honda, Goro ^{[3
]}

Kobayashi, Shin ^{[4
]}

Endo, Itaru ^{[5
]}

Hasegawa, Kiyoshi ^{[6
]}

Kotake, Kenjiro ^{[7
]}

Itabashi, Michio ^{[3
]}

Hashiguchi, Yojiro ^{[8
]}

Kotera, Yoshihito ^{[3
]}

Yamaguchi, Tatsuro ^{[9
]}

Natsume, Soichiro ^{[9
]}

Tabuchi, Ken ^{[10
]}

Kobayashi, Hirotoshi ^{[11
]}

Yamaguchi, Kensei ^{[12
]}

Morita, Satoshi ^{[13
]}

Kikuchi, Ken ^{[14
]}

Miyazaki, Masaru ^{[15
]}

Sugihara, Kenichi ^{[16
]}

Yamamoto, Masakazu ^{[17
]}

Takahashi, Keiichi ^{[18
]}

机构：

[1] Yamaga City Med Ctr, Dept Surg, 511 Yamaga, Kumamoto 8610593, Japan

[2] Ehime Univ, Dept HepatoBiliary Pancreat & Breast Surg, Grad Sch Med, Toon, Japan

[3] Tokyo Womens Med Univ, Inst Gastroenterol, Dept Surg, Shinjuku Ku, Tokyo, Japan

[4] Natl Canc Ctr Hosp East, Dept Hepatobiliary & Pancreat Surg, Kashiwa, Japan

[5] Yokohama City Univ, Dept Gastroenterol Surg, Grad Sch Med, Yokohama, Kanagawa, Japan

[6] Univ Tokyo, Grad Sch Med, Dept Surg, Hepatobiliary Pancreat Surg Div,Bunkyo Ku, Tokyo, Japan

[7] Sano City Hosp, Dept Surg, Sano, Japan

[8] Teikyo Univ, Dept Surg, Sch Med, Itabashi Ku, Tokyo, Japan

[9] Komagome Hosp, Dept Surg, Tokyo Metropolitan Canc & Infect Dis Ctr, Tokyo, Japan

[10] Komagome Hosp, Dept Pediat, Tokyo Metropolitan Canc & Infect Dis Ctr, Bunkyo Ku, Tokyo, Japan

[11] Teikyo Univ Hosp, Dept Surg, Kawasaki, Kanagawa, Japan

[12] Canc Inst Hosp Japanese Fdn Canc Res, Dept Gastrointestinal Chemotherapy, Tokyo, Japan

[13] Kyoto Univ, Grad Sch Med, Dept Biomed Stat & Bioinformat, Kyoto, Japan

[14] Sakurajuji Hosp, Kumamoto, Japan

[15] Int Univ Hlth & Welf, Narita Hosp, Chiba, Japan

[16] Tokyo Med & Dent Univ, Bunkyo Ku, Tokyo, Japan

[17] Utsunomiya Mem Hosp, Dept Surg, Utsunomiya, Tochigi, Japan

[18] Tokyo Metropolitan Hlth & Hosp Corp, Dept Surg, Ohkubo Hosp, Shinjuku Ku, Tokyo, Japan

来源：

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES | 2023年 / 30卷 / 05期

关键词：

beppu score; colorectal liver metastases; !text type='JS']JS[!/text]HBPS nomogram; modern chemotherapy; validation; HEPATECTOMY; SURVIVAL; CHEMOTHERAPY; CANCER; MODELS; SCORE;

D O I：

10.1002/jhbp.1256

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background The Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS) nomogram was developed to predict disease-free survival in patients with colorectal liver metastases (CRLM) undergoing upfront hepatectomy. However, the utility of the nomogram in patients with resected CRLM remains unknown in the current situation in which treatment strategies are changing with advances in drugs. Methods Patients in the initial nomogram cohort (n = 727) and validation cohort (n = 2225) were divided into the upfront hepatectomy and preoperative chemotherapy groups. The nomogram was validated by measuring calibration and discrimination in the two cohorts. Calibration curves were plotted, and survival probabilities were compared. Finally, to quantify the discrimination power, we estimated the concordance index (C-index). Results In the upfront hepatectomy group, the C-index was 0.63, the suitable cutoff value of the Beppu score was 7, and adjuvant chemotherapy was significantly effective limited to high-risk patients (Beppu score >= 7). The C-index was 0.56 in the preoperative chemotherapy group. Conclusions The JSHBPS nomogram remains beneficial for patients undergoing upfront hepatectomy in the recent era but is less effective for patients undergoing hepatectomy after chemotherapy. Patients with a Beppu score >= 7 showed high-risk recurrence, and adjuvant chemotherapy should be recommended for these patients.

引用

页码：591 / 601

页数：11

共 21 条

[21] Hepatic resection of non-colorectal and non-neuroendocrine liver metastases - Survival benefit for patients with non-gastrointestinal primary cancers - A case-controlled study
Slotta, Jan E.
Schuld, Jochen
Distler, Sabrina
Richter, Sven
Schilling, Martin K.
Kollmar, Otto
INTERNATIONAL JOURNAL OF SURGERY, 2014, 12 (02) : 163 - 168

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