Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy

被引：6

作者：

Thayalasekaran, Sreedhari ^{[1
]}

Bhattacharyya, Rupam ^{[1
]}

Chedgy, Fergus ^{[3
,4
]}

Basford, Peter ^{[5
]}

Subramaniam, Sharmila ^{[1
]}

Kandiah, Kesavan ^{[1
]}

Thursby-Pelham, Fergus ^{[1
]}

Brown, James ^{[2
]}

Alkandari, Asma ^{[1
]}

Ellis, Richard ^{[1
]}

Coda, Sergio ^{[1
]}

Goggin, Patrick ^{[1
]}

Amos, Mark ^{[1
]}

Fogg, Carole ^{[1
]}

Longcroft-Wheaton, Gaius ^{[1
,2
]}

Bhandari, Pradeep ^{[1
,2
]}

机构：

[1] Queen Alexandra Hosp, Dept Gastroenterol, Portsmouth PO6 3LY, Hants, England

[2] Portsmouth Univ, Pharm & Biomed Sci, Portsmouth, Hants, England

[3] Royal Sussex Cty Hosp, Dept Gastroenterol, Brighton, E Sussex, England

[4] Royal Sussex Cty Hosp, Dept Gastroenterol, Hove, E, England

[5] Western Sussex Hosp NHS Fdn Trust, Worthing, England

来源：

DIGESTIVE ENDOSCOPY | 2023年 / 35卷 / 03期

关键词：

colonic neoplasm; colonic polyp; colonoscopy; human; randomized controlled trial;

D O I：

10.1111/den.14432

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives The EndoRings device is a distal attachment consisting of two layers of circular flexible rings that evert mucosal folds. The aim of this study was to investigate whether EndoRing assisted colonoscopy (ER) improves polyp and adenoma detection compared to standard colonoscopy (SC). Methods Multicenter, parallel group, randomized controlled trial. Results Total of 556 patients randomized to ER (n = 275) or SC (n = 281). Colonoscopy completed in 532/556 (96%) cases. EndoRings removed in 74/275 (27%) patients. Total number of polyps in ER limb 582 vs. 515 in SC limb, P = 0.04. Total number of adenomas in ER limb 361 vs. 343 for SC limb, P = 0.49. A statistically significant difference in the mean number of polyps per patient in both the intention to treat (1.84 SC vs. 2.10 ER, P = 0.027) and per protocol (PP) (1.84 SC vs. 2.25 ER, P = 0.004). Conclusions Our study shows promise for the EndoRings device to improve polyp detection.

引用

页码：354 / 360

页数：7

共 12 条

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