COVID-19 and the Heart: Lessons Learned and Future Research Directions

被引：0

作者：

Lee, Tetz Cheng-Che ^{[1
,2
]}

Omar, Alaa Mabrouk Salem ^{[2
]}

Bella, Jonathan N. ^{[1
,3
]}

机构：

[1] BronxCare Hlth Syst, Bronx, NY 10457 USA

[2] Mt Sinai Morningside, New York, NY 10025 USA

[3] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

来源：

CARDIOGENETICS | 2024年 / 14卷 / 01期

关键词：

COVID-19; cardiovascular disease; long-COVID syndrome; cardiac imaging; CARDIOVASCULAR-DISEASE; MYOCARDIAL INJURY; INFECTION; ASSOCIATION; CORONAVIRUS; IMPACT;

D O I：

10.3390/cardiogenetics14010004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has become evident that acute COVID-19 infection can lead to cardiovascular complications. While the exact mechanisms by which COVID-19 affects the cardiovascular system have yet to be fully elucidated, several mechanisms have been proposed, including direct myocardial effects on the virus and systemic inflammation as an indirect result. The cardiovascular complications of COVID-19 have been characterized and described using noninvasive cardiac imaging. The impact of COVID-19 on the cardiovascular system extends beyond the acute phase of the infection and well beyond recovery or the convalescent period. However, the underlying mechanisms of post-viral long-COVID symptoms have yet to be elucidated. It is evident that COVID-19 has become endemic and is here to stay. Future studies are needed (1) to understand the long-term effects of the cardiovascular complications of COVID-19, future cardiovascular events and the impact of mutating variants on cardiovascular complications through data collection and analysis, (2) to identify the most important diagnostic criteria for prognosis of COVID-19 and to understand the disease mechanism through biomarkers and advanced cardiac imaging, including echocardiography and (3) to develop novel strategies to manage and treat these cardiovascular complications using the knowledge gained.

引用

页码：51 / 58

页数：8

共 68 条

[1] Patients with COVID-19: in the dark-NETs of neutrophils [J].

Ackermann, Maximilian ;

Anders, Hans-Joachim ;

Bilyy, Rostyslav ;

Bowlin, Gary L. ;

Daniel, Christoph ;

De Lorenzo, Rebecca ;

Egeblad, Mikala ;

Henneck, Timo ;

Hidalgo, Andres ;

Hoffmann, Markus ;

Hohberger, Bettina ;

Kanthi, Yogendra ;

Kaplan, Mariana J. ;

Knight, Jason S. ;

Knopf, Jasmin ;

Kolaczkowska, Elzbieta ;

Kubes, Paul ;

Leppkes, Moritz ;

Mahajan, Aparna ;

Manfredi, Angelo A. ;

Maueroeder, Christian ;

Maugeri, Norma ;

Mitroulis, Ioannis ;

Munoz, Luis E. ;

Narasaraju, Teluguakula ;

Naschberger, Elisabeth ;

Neeli, Indira ;

Ng, Lai Guan ;

Radic, Marko Z. ;

Ritis, Konstantinos ;

Rovere-Querini, Patrizia ;

Schapher, Mirco ;

Schauer, Christine ;

Simon, Hans-Uwe ;

Singh, Jeeshan ;

Skendros, Panagiotis ;

Stark, Konstantin ;

Stuerzl, Michael ;

van der Vlag, Johan ;

Vandenabeele, Peter ;

Vitkov, Ljubomir ;

von Koeckritz-Blickwede, Maren ;

Yanginlar, Cansu ;

Yousefi, Shida ;

Zarbock, Alexander ;

Schett, Georg ;

Herrmann, Martin .

CELL DEATH AND DIFFERENTIATION, 2021, 28 (11) :3125-3139

[2] Long COVID after breakthrough SARS-CoV-2 infection [J].

Al-Aly, Ziyad ;

Bowe, Benjamin ;

Xie, Yan .

NATURE MEDICINE, 2022, 28 (07) :1461-+

[3] Echocardiographic Findings in Patients With COVID-19 With Myocardial Injury During the Omicron Variant Surge [J].

Alam, Loba ;

Omar, Alaa Mabrouk Salem ;

Talebi, Soheila ;

Narula, Jagat ;

Argulian, Edgar .

AMERICAN JOURNAL OF CARDIOLOGY, 2022, 172 :168-169

[4]

[Anonymous], 2020, LANCET HAEMATOL, V7, pE425, DOI 10.1016/S2352-3026(20)30151-4

[5] Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study [J].

Ayoubkhani, Daniel ;

Khunti, Kamlesh ;

Nafilyan, Vahe ;

Maddox, Thomas ;

Humberstone, Ben ;

Diamond, Ian ;

Banerjee, Amitava .

BMJ-BRITISH MEDICAL JOURNAL, 2021, 372

[6] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[7] ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 2-care pathways, treatment, and follow-up [J].

Baigent, Colin ;

Windecker, Stephan ;

Andreini, Daniele ;

Arbelo, Elena ;

Barbato, Emanuele ;

Bartorelli, Antonio L. ;

Baumbach, Andreas ;

Behr, Elijah R. ;

Berti, Sergio ;

Bueno, Hector ;

Capodanno, Davide ;

Cappato, Riccardo ;

Chieffo, Alaide ;

Collet, Jean-Philippe ;

Cuisset, Thomas ;

de Simone, Giovanni ;

Delgado, Victoria ;

Dendale, Paul ;

Dudek, Dariusz ;

Edvardsen, Thor ;

Elvan, Arif ;

Gonzalez-Juanatey, Jose R. ;

Gori, Mauro ;

Grobbee, Diederick ;

Guzik, Tomasz J. ;

Halvorsen, Sigrun ;

Haude, Michael ;

Heidbuchel, Hein ;

Hindricks, Gerhard ;

Ibanez, Borja ;

Karam, Nicole ;

Katus, Hugo ;

Klok, Fredrikus A. ;

Konstantinides, Stavros, V ;

Landmesser, Ulf ;

Leclercq, Christophe ;

Leonardi, Sergio ;

Lettino, Maddalena ;

Marenzi, Giancarlo ;

Mauri, Josepa ;

Metra, Marco ;

Morici, Nuccia ;

Mueller, Christian ;

Petronio, Anna Sonia ;

Polovina, Marija M. ;

Potpara, Tatjana ;

Praz, Fabien ;

Prendergast, Bernard ;

Prescott, Eva ;

Price, Susanna .

EUROPEAN HEART JOURNAL, 2022, 43 (11) :1059-1103

[8] Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease [J].

Bergamaschi, Laura ;

Mescia, Federica ;

Turner, Lorinda ;

Hanson, Aimee L. ;

Kotagiri, Prasanti ;

Dunmore, Benjamin J. ;

Ruffieux, Helene ;

De Sa, Aloka ;

Huhn, Oisin ;

Morgan, Michael D. ;

Gerber, Pehuen Pereyra ;

Wills, Mark R. ;

Baker, Stephen ;

Calero-Nieto, Fernando J. ;

Doffinger, Rainer ;

Dougan, Gordon ;

Elmer, Anne ;

Goodfellow, Ian G. ;

Gupta, Ravindra K. ;

Hosmillo, Myra ;

Hunter, Kelvin ;

Kingston, Nathalie ;

Lehner, Paul J. ;

Matheson, Nicholas J. ;

Nicholson, Jeremy K. ;

Petrunkina, Anna M. ;

Richardson, Sylvia ;

Saunders, Caroline ;

Thaventhiran, James E. D. ;

Toonen, Erik J. M. ;

Weekes, Michael P. ;

Gottgens, Berthold ;

Toshner, Mark ;

Hess, Christoph ;

Bradley, John R. ;

Lyons, Paul A. ;

Smith, Kenneth G. C. .

IMMUNITY, 2021, 54 (06) :1257-+

[9] COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow [J].

Bikdeli, Behnood ;

Madhavan, Mahesh V. ;

Jimenez, David ;

Chuich, Taylor ;

Dreyfus, Isaac ;

Driggin, Elissa ;

Der Nigoghossian, Caroline ;

Ageno, Walter ;

Madjid, Mohammad ;

Guo, Yutao ;

Tang, Liang V. ;

Hu, Yu ;

Giri, Jay ;

Cushman, Mary ;

Quere, Isabelle ;

Dimakakos, Evangelos P. ;

Gibson, C. Michael ;

Lippi, Giuseppe ;

Favaloro, Emmanuel J. ;

Fareed, Jawed ;

Caprini, Joseph A. ;

Tafur, Alfonso J. ;

Burton, John R. ;

Francese, Dominic P. ;

Wang, Elizabeth Y. ;

Falanga, Anna ;

McLintock, Claire ;

Hunt, Beverley J. ;

Spyropoulos, Alex C. ;

Barnes, Geoffrey D. ;

Eikelboom, John W. ;

Weinberg, Ido ;

Schulman, Sam ;

Carrier, Marc ;

Piazza, Gregory ;

Beckman, Joshua A. ;

Steg, Gabriel ;

Stone, Gregg W. ;

Rosenkranz, Stephan ;

Goldhaber, Samuel Z. ;

Parikh, Sahil A. ;

Monreal, Manuel ;

Krumholz, Harlan M. ;

Konstantinides, Stavros V. ;

Weitz, Jeffrey I. ;

Lip, Gregory Y. H. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (23) :2950-2973

[10]

Boehmer TK, 2021, MMWR-MORBID MORTAL W, V70, P1228, DOI 10.15585/mmwr.mm7035e5

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