Bioceramic materials in bone-implantable drug delivery systems: A review

被引：8
作者：
Nayak, Amit Kumar [1 ,6 ]
Maity, Mala [2 ]
Barik, Harekrushna [3 ]
Behera, Sidhartha Sankar [4 ]
Dhara, Amal Kumar [5 ]
Hasnain, Md Saquib [3 ]
机构：
[1] Siksha O Anusandhan Deemed Be Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Bhubaneswar 751003, Orissa, India
[2] Anand Coll Educ, Dept Pharm, Kolkata 721126, W Bengal, India
[3] Palamau Inst Pharm, Dept Pharm, Daltonganj 822102, Jharkhand, India
[4] Odisha Univ Agr & Technol, Coll Vet Sci & Anim Husb, Dept Vet Surg & Radiol, Bhubaneswar 751003, Orissa, India
[5] Contai Polytech, Dept Pharm, Contai 721401, W Bengal, India
[6] Siksha O Anusandhan Deemed be Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Bhubaneswar, Orissa, India
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2024年 / 95卷
关键词：
Bioceramic; Bone-implants; Bone drug delivery; Bone regeneration; Osteomyelitis; MESOPOROUS BIOACTIVE GLASS; CALCIUM-SULFATE BEADS; IN-VITRO EVALUATION; ANTIBACTERIAL ACTIVITY; NANO-HYDROXYAPATITE; GROWTH-FACTOR; PHOSPHATE; VANCOMYCIN; SCAFFOLDS; OSTEOMYELITIS;
D O I：
10.1016/j.jddst.2024.105524
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since long, the applications of bioceramics in bone-implantable drug delivery has revealed a significant impact due to some favorable merits, such as excellent biocompatibility, good bioactivity, nonimmunogenicity, osteoconductivity, bone resorbability and controllable porous microstructure. To treat different disorders and diseases, such as fracture, osteoporosis, osteoarthritis, osteomyelitis, osseous cancer, etc., various drug releasing bone-implants composed of bioceramics have widely been investigated. During the last few decades, a large number of drugs (like antibiotics, anticancer agents, anti-inflammatory agents, proteins and peptides, growth factors, etc.) have been investigated for the controlled release by bone-implants made up of bioceramics. Amongst various bioceramics, calcium sulfate, calcium phosphates and bioactive glasses are being mostly used in the formula of drug releasing bone-implants. This review article describes about different bioceramic materials, which are being used to formulate drug releasing bone-implants to treat different bone diseases and disorders.
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页数：18
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