Diprenylated phenolic enantiomers from Artemisia scoparia

被引：1
作者：
Kuerban, Guziliayi [1 ,2 ,3 ]
Turak, Ablajan [1 ,2 ]
Zhao, Jiangyu [1 ,2 ,3 ]
Aisa, Haji Akber [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, State Key Lab Basis Xinjiang Indigenous Med Plants, Urumqi 830011, Peoples R China
[2] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
PHYTOCHEMISTRY | 2024年 / 219卷
关键词：
Artemisia scoparia; Asteraceae; Prenylated phenolics; Enantiomer; Anti-inflammatory; CHEMICAL-COMPOSITION; ANTIOXIDANT ACTIVITY; ESSENTIAL OIL; CONSTITUENTS;
D O I：
10.1016/j.phytochem.2024.113991
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Investigation on the chemical constituents of Artemisia scoparia resulted in the isolation of sixteen compounds, including undescribed six pairs of diprenylated phenolic enantiomers (+/-)-scopacoumaricin A -F, and two pairs of cis-trans isomers cis/trans-scopacoumaricin G and cis/trans-artepillin A. Trans-artepillin A was obtained from this plant for the first time. The structures of the isolates were proposed by analysis of their 1D, 2D-NMR and HRESIMS spectroscopic data. Their absolute configurations were determined by comparison of their experimental and calculated electronic circular dichroism spectra. Evaluations of the anti-inflammatory activity revealed that (-)-scopacoumaricin D, (+)-scopacoumaricin F and cis-scopacoumaricin G showed moderate antiinflammatory activity on lipopolysaccharide-induced nitric oxide production in RAW264.7 cell.
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