Third-generation CD19.CAR-T cell-containing combination therapy in Scl70+systemic sclerosis

被引：72

作者：

Merkt, Wolfgang ^{[1
,9
]}

Freitag, Merle ^{[1
]}

Claus, Maren ^{[2
]}

Kolb, Philipp ^{[3
,4
]}

Falcone, Valeria ^{[3
,4
]}

Roehrich, Manuel ^{[5
,6
]}

Rodon, Lea ^{[1
]}

Deicher, Franca ^{[1
]}

Andreeva, Ivana ^{[1
]}

Tretter, Theresa ^{[1
]}

Tykocinski, Lars-Oliver ^{[1
]}

Blank, Norbert ^{[1
]}

Watzl, Carsten ^{[2
]}

Schmitt, Anita ^{[1
]}

Sauer, Tim ^{[1
]}

Mueller-Tidow, Carsten ^{[1
]}

Polke, Markus ^{[7
]}

Heussel, Claus Peter ^{[8
]}

Dreger, Peter ^{[1
]}

Lorenz, Hanns-Martin ^{[1
]}

Schmitt, Michael ^{[1
]}

机构：

[1] Univ Hosp Heidelberg, Dept Hematol Oncol & Rheumatol, Internal Med 5, Heidelberg, Germany

[2] TU Dortmund IfADo, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany

[3] Univ Med Ctr, Inst Virol, Freiburg, Germany

[4] Albert Ludwigs Univ Freiburg, Fac Med, Freiburg, Germany

[5] Univ Hosp Heidelberg, Dept Nucl Med, Heidelberg, Germany

[6] Univ Hosp Mainz, Dept Nucl Med, Mainz, Germany

[7] Univ Hosp Heidelberg, Thoraxklin, Ctr Interstitial & Rare Lung Dis, Heidelberg, Germany

[8] Univ Hosp Heidelberg, Thoraxklin, Diagnost & Intervent Radiol Nucl Med, Heidelberg, Germany

[9] Univ Hosp Heidelberg, Dept Hematol Oncol & Rheumatol, Internal Med 5, Heidelberg, Baden Wurttembe, Germany

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2024年 / 83卷 / 04期

关键词：

Scleroderma; Autoimmune Diseases; Pulmonary Fibrosis; Immune Complex Diseases; Systemic;

D O I：

10.1136/ard-2023-225174

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：543 / 546

页数：4

共 16 条

[1] Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells [J].

Bergmann, Christina ;

Mueller, Fabian ;

Distler, Joerg H. W. ;

Gyoerfi, Andrea-Hermina ;

Voelkl, Simon ;

Aigner, Michael ;

Kretschmann, Sascha ;

Reimann, Hannah ;

Harrer, Thomas ;

Bayerl, Nadine ;

Boeltz, Sebastian ;

Wirsching, Andreas ;

Taubmann, Jule ;

Roesler, Wolf ;

Spriewald, Bernd ;

Wacker, Jochen ;

Atzinger, Armin ;

Uder, Michael ;

Kuwert, Torsten ;

Mackensen, Andreas ;

Schett, Georg .

ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 (08) :1117-1120

[2] Visual vs Fully Automatic Histogram-Based Assessment of Idiopathic Pulmonary Fibrosis (IPF) Progression Using Sequential Multidetector Computed Tomography (MDCT) [J].

Colombi, Davide ;

Dinkel, Julien ;

Weinheimer, Oliver ;

Obermayer, Berenike ;

Buzan, Teodora ;

Nabers, Diana ;

Bauer, Claudia ;

Oltmanns, Ute ;

Palmowski, Karin ;

Herth, Felix ;

Kauczor, Hans Ulrich ;

Sverzellati, Nicola ;

Kreuter, Michael ;

Heussel, Claus Peter .

PLOS ONE, 2015, 10 (06)

[3] SERUM IMMUNE-COMPLEXES IN SYSTEMIC-SCLEROSIS - RELATIONSHIP WITH PRECIPITATING NUCLEAR ANTIBODIES [J].

FRENCH, MAH ;

HARRISON, G ;

PENNING, CA ;

CUNNINGHAM, J ;

HUGHES, P ;

ROWELL, NR .

ANNALS OF THE RHEUMATIC DISEASES, 1985, 44 (02) :89-92

[4] Fludarabine-related pulmonary toxicity - A distinct clinical entity in chronic lymphoproliferative syndromes [J].

Helman, DL ;

Byrd, JC ;

Ales, NC ;

Shorr, AF .

CHEST, 2002, 122 (03) :785-790

[5] Obinutuzumab in connective tissue diseases after former rituximab-non-response: a case series [J].

Kvacskay, Peter ;

Merkt, Wolfgang ;

Gunther, Janine ;

Blank, Norbert ;

Lorenz, Hanns-Martin .

ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (05) :744-746

[6] CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis [J].

Lande, Roberto ;

Lee, Ernest Y. ;

Palazzo, Raffaella ;

Marinari, Barbara ;

Pietraforte, Immacolata ;

Santos, Giancarlo Santiago ;

Mattenberger, Yves ;

Spadaro, Francesca ;

Stefanantoni, Katia ;

Iannace, Nicoletta ;

Dufour, Aleksandra Maria ;

Falchi, Mario ;

Bianco, Manuela ;

Botti, Elisabetta ;

Bianchi, Luca ;

Alvarez, Montserrat ;

Riccieri, Valeria ;

Truchetet, Marie-Elise ;

Wong, Gerard C. L. ;

Chizzolini, Carlo ;

Frasca, Loredana .

NATURE COMMUNICATIONS, 2019, 10 (1)

[7] CD19 CAR T cell therapy effective for systemic lupus erythematosus [J].

Gelfand, J. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 143 (01) :4-4

[8] Rituximab and mycophenolate mofetil combination in patients with interstitial lung disease (EVER-ILD): a double-blind, randomised, placebo-controlled trial [J].

Mankikian, Julie ;

Caille, Agnes ;

Reynaud-Gaubert, Martine ;

Agier, Marie-Sara ;

Bermudez, Julien ;

Bonniaud, Philippe ;

Borie, Raphael ;

Brillet, Pierre-Yves ;

Cadranel, Jacques ;

Court-Fortune, Isabelle ;

Crestani, Bruno ;

Debray, Marie-Pierre ;

Gomez, Emmanuel ;

Gondouin, Anne ;

Hirschi-Santelmo, Sandrine ;

Israel-Biet, Dominique ;

Jouneau, Stephane ;

Juvin, Karine ;

Leger, Julie ;

Kerjouan, Mallorie ;

Marquette, Charles-Hugo ;

Naccache, Jean-Marc ;

Nunes, Hilario ;

Plantier, Laurent ;

Prevot, Gregoire ;

Quetant, Sebastien ;

Traclet, Julie ;

Valentin, Victor ;

Uzunhan, Yurdagul ;

Wemeau-Stervinou, Lidwine ;

Bejan-Angoulvant, Theodora ;

Cottin, Vincent ;

Marchand-Adam, Sylvain .

EUROPEAN RESPIRATORY JOURNAL, 2023, 61 (06)

[9] CD19-targeted CAR T cells in refractory antisynthetase syndrome [J].

Mueller, Fabian ;

Boeltz, Sebastian ;

Knitza, Johannes ;

Aigner, Michael ;

Voelkl, Simon ;

Kharboutli, Soraya ;

Reimann, Hannah ;

Taubmann, Jule ;

Kretschmann, Sascha ;

Roesler, Wolf ;

Manger, Bernhard ;

Wacker, Jochen ;

Mougiakakos, Dimitrios ;

Jabari, Samir ;

Schroeder, Rolf ;

Uder, Michael ;

Roemer, Frank ;

Kroenke, Gerhard ;

Mackensen, Andreas ;

Schett, Georg .

LANCET, 2023, 401 (10379) :815-818

[10]

PENNING CA, 1984, CLIN EXP IMMUNOL, V57, P548

← 1 2 →