Inflammation in Heart Failure-Future Perspectives

被引：21

作者：

Arvunescu, Alexandru Mircea ^{[1
,2
]}

Ionescu, Ruxandra Florentina ^{[3
,4
]}

Cretoiu, Sanda Maria ^{[4
]}

Dumitrescu, Silviu Ionel ^{[3
,5
]}

Zaharia, Ondin ^{[1
,2
]}

Nanea, Ioan Tiberiu ^{[1
,2
]}

机构：

[1] Prof Dr Th Burghele Clin Hosp, Dept Internal Med & Cardiol, Bucharest 061344, Romania

[2] Carol Davila Univ Med & Pharm, Fac Med, Dept Cardiothorac Pathol, Cardiothorac Pathol, Bucharest 050471, Romania

[3] Cent Mil Emergency Hosp Dr Carol Davila, Dept Cardiol 1, Bucharest 030167, Romania

[4] Carol Davila Univ Med & Pharm, Dept Morphol Sci Cell & Mol Biol & Histol, Bucharest 050474, Romania

[5] Titu Maiorescu Univ, Fac Med, Dept Cardiol, Bucharest 040441, Romania

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 24期

关键词：

heart failure; inflammation; proinflammatory cytokines; TNF-alpha; CRP; fibrinogen; IL-1; IL-6; iNOS; myeloperoxidase; NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; PRESERVED EJECTION FRACTION; ACUTE MYOCARDIAL-INFARCTION; EPICARDIAL ADIPOSE-TISSUE; FACTOR-ALPHA; TNF-ALPHA; DIASTOLIC DYSFUNCTION; CARDIOGENIC-SHOCK;

D O I：

10.3390/jcm12247738

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic heart failure is a terminal point of a vast majority of cardiac or extracardiac causes affecting around 1-2% of the global population and more than 10% of the people above the age of 65. Inflammation is persistently associated with chronic diseases, contributing in many cases to the progression of disease. Even in a low inflammatory state, past studies raised the question of whether inflammation is a constant condition, or if it is, rather, triggered in different amounts, according to the phenotype of heart failure. By evaluating the results of clinical studies which focused on proinflammatory cytokines, this review aims to identify the ones that are independent risk factors for heart failure decompensation or cardiovascular death. This review assessed the current evidence concerning the inflammatory activation cascade, but also future possible targets for inflammatory response modulation, which can further impact the course of heart failure.

引用

页数：25

共 192 条

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