Role of exosomes in prostate cancer and male fertility

被引：6

作者：

Dey, Dwaipayan ^{[1
]}

Ghosh, Srestha ^{[2
]}

Mirgh, Divya ^{[3
]}

Panda, Siva Parsad ^{[4
]}

Jha, Niraj Kumar ^{[5
,6
,7
]}

Jha, Saurabh Kumar ^{[5
,8
,9
]}

机构：

[1] Ramakrishna Mission Vivekananda Centenary Coll, Dept Microbiol, Rahara 700118, West Bengal, India

[2] Lady Brabourne Coll, Dept Microbiol, Kolkata 700017, West Bengal, India

[3] Johns Hopkins Univ, Baltimore, MD 21218 USA

[4] GLA Univ, Inst Pharmaceut Res, Mathura 281406, Uttar Pradesh, India

[5] Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, India

[6] Lovely Profess Univ, Sch Bioengn & Biosci, Phagwara 144411, India

[7] Chandigarh Univ, Dept Biotechnol Engn & Food Technol, Mohali 140413, India

[8] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Chennai, India

[9] Uttaranchal Univ, Sch Appl & Life Sci SALS, Dept Biotechnol, Dehra Dun, India

来源：

DRUG DISCOVERY TODAY | 2023年 / 28卷 / 11期

关键词：

exosomes; prostate cancer; metastasis; seminal exosomes; therapeutic; TUMOR-DERIVED EXOSOMES; ANHYDRASE IX EXPRESSION; DRUG-RESISTANCE; MICRORNAS; CELLS; VESICLES; MIRNAS; TECHNOLOGIES; PROGRESSION; METASTASIS;

D O I：

10.1016/j.drudis.2023.103791

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prostate cancer (PCa) is the second most common and fifth most aggressive neoplasm among men worldwide. In the last decade, extracellular vesicle (EV) research has decoded multiple unsolved cancer-related mysteries. EVs can be classified as microvesicles, apoptotic bodies, and exosomes, among others. Exosomes play a key role in cellular signaling. Their internal cargos (nucleic acids, proteins, lipids) influence the recipient cell. In PCa, the exosome is the regulator of cancer progression. It is also a promising theranostics tool for PCa. Moreover, exosomes have strong participation in male fertility complications. This review aims to highlight the exosome theranostics signature in PCa and its association with male fertility.

引用

页数：10

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