A high level of thyroid-stimulating hormone is a risk factor for the development of chronic kidney disease in men: a 10-year cohort study

被引:2
作者
Endo, Keisuke [1 ]
Tanaka, Marenao [1 ,2 ]
Sato, Tatsuya [1 ,3 ]
Mori, Kazuma [4 ]
Hosaka, Itaru [5 ]
Mikami, Takuma [5 ]
Umetsu, Araya [6 ]
Akiyama, Yukinori [7 ]
Ohnishi, Hirofumi [1 ,8 ]
Hanawa, Nagisa [9 ]
Furuhashi, Masato [1 ]
机构
[1] Sapporo Med Univ, Sch Med, Dept Cardiovasc Renal & Metab Med, Sapporo, Japan
[2] Tanaka Med Clin, Yoichi, Japan
[3] Sapporo Med Univ, Sch Med, Dept Cellular Physiol & Signal Transduct, Sapporo, Japan
[4] Natl Def Med Coll, Dept Immunol & Microbiol, Tokorozawa, Japan
[5] Sapporo Med Univ, Sch Med, Dept Cardiovasc Surg, Sapporo, Japan
[6] Sapporo Med Univ, Sch Med, Dept Ophthalmol, Sapporo, Japan
[7] Sapporo Med Univ, Sch Med, Dept Neurosurg, Sapporo, Japan
[8] Sapporo Med Univ, Sch Med, Dept Publ Hlth, Sapporo, Japan
[9] Keijinkai Maruyama Clin, Dept Hlth Checkup & Promot, Sapporo, Japan
关键词
thyroid-stimulating hormone; hypothyroidism; chronic kidney disease; HYPOTHYROIDISM; ASSOCIATION; DYSFUNCTION; POPULATION; PREVALENCE; OUTCOMES;
D O I
10.1038/s41440-023-01453-1
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Hypothyroidism has been reported to be associated with chronic kidney disease (CKD). However, the impact of thyroid-stimulating hormone (TSH) on new onset of CKD and its gender dependence remain undetermined. We investigated the association of serum TSH level and the development of CKD defined by estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 or positive for urine protein in 28,990 Japanese subjects who received annual health examinations. After excluding subjects with no data for serum TSH, urinalysis and eGFR and those with CKD at baseline, a total of 10,392 subjects (men/women: 6802/3590, mean age: 48 years) were recruited. During a 10-year follow-up, 1185 men (6.7%) and 578 women (2.9%) newly developed CKD. Multivariable Cox proportional hazard models after adjustment of age, body mass index, smoking habit, hypertension, diabetes mellitus, dyslipidemia, ischemic heart disease and eGFR (<= 90 mL/min/1.73 m(2)) showed that the hazard ratio (HR) for the development of CKD in the high TSH (> 4.2 mU/L) group was significantly higher than that in the low TSH (<= 4.2 mU/L) group in men (HR [95% confidence interval]: 1.41 [1.09-1.83]) but not in women (1.08 [0.77-1.51]). There was a significant interaction between sex and the category of TSH level for the development of CKD (p = 0.02). The adjusted HR with a restricted cubic spline increased with a higher level of TSH in men but not in women. In conclusion, a high level of TSH is associated with an increased risk for the development of CKD in men but not in women.
引用
收藏
页码:663 / 671
页数:9
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