Brain disorders are currently one of the world's most serious and difficult health issues. These brain disorders are accountable for a massive number of morbidities and mortalities around the world. The current treatments of these disorders are frequently accompanied by severe side effects and cause a detrimental effect on health. Recently, plant flavonoids have sparked a surge in public and scientific attention because of their alleged health-promoting impact and almost no adverse repercussions. Also, scientific research has shown that phytochemicals possess numerous neuroprotective properties under in vivo and in vitro conditions. Chrysin is a therapeutic phytochemical that falls under the class of flavonoids based on its structure. The biological activities and pharmacological effects of chrysin include anticancer, antioxidant, and anti-inflammatory activities as well as amyloidogenic and neurotrophic effects. These therapeutic abilities of chrysin are attributed to its structural diverseness arising in ring-A and lack of oxygenation in B and C rings. Several studies have highlighted the rising significance of chrysin in a variety of brain illnesses, like Alzheimer's disease, Parkinson's disease, depression, anxiety, brain tumours, epilepsy, multiple sclerosis, traumatic brain injury, spinal cord injury, and ischemic stroke. This study depicts the relationship of chrysin with different brain-related disorders and discusses the mechanisms responsible for the potential role of chrysin as a pharmacological agent for the treatment and management of different brain disorders based on the results of several preclinical studies and taking into account the therapeutic effects of the compound.
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Kashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, IranKashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran
Motamedzadeh, Alireza
Rahmati-Dehkordi, Fatemeh
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Univ Tehran Med Sci, Neurosci Inst, Electrophysiol Res Ctr, Tehran, Iran
Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, IranKashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran
Rahmati-Dehkordi, Fatemeh
Heydari, Hoora
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Ardabil Univ Med Sci, Student Res Comm, Ardebil, IranKashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran
Heydari, Hoora
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Behnam, Mohammad
Noshabad, Fatemeh Zahra Rashidi
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Kashan Univ Med Sci, Student Res Comm, Kashan, IranKashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran
Noshabad, Fatemeh Zahra Rashidi
Tamtaji, Zeinab
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Kashan Univ Med Sci, Student Res Comm, Kashan, IranKashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran
Tamtaji, Zeinab
Taheri, Abdolkarim Talebi
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Univ Tehran Med Sci, Sch Med, Dept Clin Biochem, Tehran, IranKashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran
Taheri, Abdolkarim Talebi
Nabavizadeh, Fatemeh
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Univ Tehran Med Sci, Neurosci Inst, Electrophysiol Res Ctr, Tehran, Iran
Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, IranKashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran
Nabavizadeh, Fatemeh
Aschner, Michael
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Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USAKashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran
Aschner, Michael
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Mirzaei, Hamed
Tamtaji, Omid Reza
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Univ Tehran Med Sci, Neurosci Inst, Electrophysiol Res Ctr, Tehran, Iran
Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Univ Tehran Med Sci, Sch Med, Dept Physiol, Tehran, IranKashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran
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Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University,Assiut BranchDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University,Assiut Branch
Fares EM Ali
Mostafa K Abd El-Aziz
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Faculty of Pharmacy, Al-Azhar University,Assiut BranchDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University,Assiut Branch
Mostafa K Abd El-Aziz
Elham I Sharab
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Faculty of Pharmacy, Al-Azhar University,Assiut BranchDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University,Assiut Branch
Elham I Sharab
Adel G Bakr
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Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University,Assiut BranchDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University,Assiut Branch