Crosstalk between the gut microbiota and innate lymphoid cells in intestinal mucosal immunity

被引：17

作者：

Guo, Yuling ^{[1
]}

Liu, Yujia ^{[1
]}

Rui, Binqi ^{[1
]}

Lei, Zengjie ^{[1
]}

Ning, Xixi ^{[1
]}

Liu, Yinhui ^{[1
]}

Li, Ming ^{[1
]}

机构：

[1] Dalian Med Univ, Coll Basic Med, Dept Microecol, Dalian, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

gut microbiota; innate lymphoid cells; lamina propria; diseases; intestinal mucosal immunity; ARYL-HYDROCARBON RECEPTOR; TISSUE-INDUCER CELLS; NATURAL-KILLER-CELLS; ROR-GAMMA-T; GERM-FREE MICE; HOST-DEFENSE; NUCLEAR RECEPTOR; EPITHELIAL-CELLS; MOLECULAR ANALYSIS; FOLLICLE FORMATION;

D O I：

10.3389/fimmu.2023.1171680

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human gastrointestinal mucosa is colonized by thousands of microorganisms, which participate in a variety of physiological functions. Intestinal dysbiosis is closely associated with the pathogenesis of several human diseases. Innate lymphoid cells (ILCs), which include NK cells, ILC1s, ILC2s, ILC3s and LTi cells, are a type of innate immune cells. They are enriched in the mucosal tissues of the body, and have recently received extensive attention. The gut microbiota and its metabolites play important roles in various intestinal mucosal diseases, such as inflammatory bowel disease (IBD), allergic disease, and cancer. Therefore, studies on ILCs and their interaction with the gut microbiota have great clinical significance owing to their potential for identifying pharmacotherapy targets for multiple related diseases. This review expounds on the progress in research on ILCs differentiation and development, the biological functions of the intestinal microbiota, and its interaction with ILCs in disease conditions in order to provide novel ideas for disease treatment in the future.

引用

页数：18

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