Method development for the quantification of lead levels in whole blood sampled on Mitra(R) with VAMS(R) tips by inductively coupled plasma-MS/MS

被引：4

作者：

Breton, Anthony ^{[1
,2
]}

Cirtiu, Ciprian Mihai ^{[1
,2
]}

Fleury, Normand ^{[1
]}

Lajeunesse, Andre ^{[2
]}

Rudge, James ^{[3
]}

机构：

[1] Inst Natl Sante publ Quebec INSPQ, Ctr toxicol Quebec CTQ, 945 Wolfe, Quebec City, PQ G1V 5B3, Canada

[2] Univ Quebec Trois Rivieres UQTR, Dept Chem Biochem & Phys, 3351 boul Forges, Quebec City, PQ G9A 5H7, Canada

[3] Crownhill Business Ctr, Trajan Sci & Med, 14 Vincent Ave, Milton Keynes MK8 0AB, England

来源：

BIOANALYSIS | 2023年 / 15卷 / 02期

关键词：

blood lead level (BLL); ICP-MS/MS; lead (Pb); volumetric absorptive microsampling (VAMS(R)); whole blood; MULTIPLE ELEMENTS;

D O I：

10.4155/bio-2022-0242

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Lead is harmful for humans by having adverse effects on different biological systems. Venepuncture is the gold standard for blood lead level analysis, but this method has many flaws. The goal of this research was to develop and validate a more practical approach for blood sampling. Materials & methods: Mitra(R) devices based on VAMS(R) and inductively coupled plasma-MS/MS technologies were employed. Performance evaluation of the newly developed method was also performed by comparing it versus a commonly used method at the Centre de Toxicologie du Quebec for blood lead level analysis. Results: Comparison showed no signs of significant difference between the two methods. Conclusion: VAMS may be a useful alternative sampling approach for further research on blood lead analysis and possibly for many other trace elements.

引用

页码：71 / 81

页数：11

共 25 条

[1] Determination of ultra-trace amounts of prosthesis-related metals in whole blood using volumetric absorptive micro-sampling and tandem ICP - Mass spectrometry
Bolea-Fernandez, Eduardo
Phan, Kim
Balcaen, Lieve
Resano, Martin
Vanhaecke, Frank
[J]. ANALYTICA CHIMICA ACTA, 2016, 941 : 1 - 9
[2] Analysis of whole blood by ICP-MS equipped with a high temperature total sample consumption system
Canabate, Agueda
Garcia-Ruiz, Esperanza
Resano, Martin
Todoli, Jose-Luis
[J]. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 2017, 32 (01) : 78 - 87
[3] Hematocrit prediction in volumetric absorptive microsamples
Capiau, Sara
Stove, Christophe
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 190
[4] Development, validation and application of an inductively coupled plasma - mass spectrometry method to determine cobalt in metal-on-metal prosthesis patients using volumetric absorptive microsampling
Capiau, Sara
Bolea-Fernandez, Eduardo
Balcaen, Lieve
Van Der Straeten, Catherine
Verstraete, Alain G.
Vanhaecke, Frank
Stove, Christophe P.
[J]. TALANTA, 2020, 208
[5] CAWTE J, 1987, LANCET, V1, P1257
[6] Centers for Disease Control and Prevention (CDC), 2023, Childhood lead poisoning prevention. Sources of lead exposure
[7] Dart RC., 2004, MED TOXICOL, P1796
[8] Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study
De Kesel, Pieter M. M.
Lambert, Willy E.
Stove, Christophe P.
[J]. ANALYTICA CHIMICA ACTA, 2015, 881 : 65 - 73
[9] Alternative Sampling Devices to Collect Dried Blood Microsamples: State-of-the-Art
Delahaye, Lisa
Veenhof, Herman
Koch, Birgit C. P.
Alffenaar, Jan-Willem C.
Linden, Rafael
Stove, Christophe
[J]. THERAPEUTIC DRUG MONITORING, 2021, 43 (03) : 310 - 321
[10] Volumetric Absorptive Microsampling: A Dried Sample Collection Technique for Quantitative Bioanalysis
Denniff, Philip
Spooner, Neil
[J]. ANALYTICAL CHEMISTRY, 2014, 86 (16) : 8489 - 8495

← 1 2 3 →