Antileukemia and Anticolorectal Cancer Activity of Janus Dendrimer Conjugates with Naproxen and Ibuprofen

The synthesis of a non-steroidal anti-inflammatory dendritic drug carrier, naproxen and ibuprofen-based poly-ester Janus dendrimer was carried out using a conventional azide-alkyne click-chemistry reaction. The corresponding dendron linkers contain naproxen and ibuprofen drug moieties on the surface and a stable [1,2,3]-triazole as focal nucleus. The Janus dendrimer conjugate with four naproxen in one face and four ibuprofen on the other face was very active against human chronic myelogenous leukemia (K-562) and human colorectal adenocarcinoma (HCT-15) cells compared with cisplatin. This design provided an effective pathway for the synthesis of multiple drug carriers with two or more different end drugs in the structure.