Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023

被引：24

作者：

Maubaret, Clara ^{[1
,2
,3
]}

Camelena, Francois ^{[1
,2
,3
]}

Mrimeche, Manel ^{[1
,2
,3
]}

Braille, Aymeric ^{[2
,3
]}

Liberge, Mathilde ^{[1
,2
,3
]}

Mainardis, Mary ^{[2
,3
]}

Guillaume, Clemence ^{[4
]}

Noels, Franck ^{[5
]}

Bebear, Cecile ^{[6
,7
]}

Molina, Jean-Michel ^{[8
,9
]}

Lot, Florence ^{[10
]}

Chazelle, Emilie ^{[10
]}

Bercot, Beatrice ^{[1
,2
,3
]}

机构：

[1] Paris Cite Univ, INSERM 1137, IAME, Paris, France

[2] St Louis Lariboisiere Univ Hosp, APHP, Infect Agents Dept, Microbiol Lab, Paris, France

[3] French Natl Reference Ctr Bacterial STIs, Associated Lab Gonococci, Paris, France

[4] Orleans Hosp, Microbiol Lab, Orleans, France

[5] Microbiol Lab, Bioxa Lab, Bezannes, France

[6] Univ Bordeaux, USC EA Mycoplasmal & Chlamydial Infect Humans 3671, Bordeaux, France

[7] Univ Hosp, French Natl Reference Ctr Bacterial STIs, Bacteriol Dept, Bordeaux, France

[8] Paris Cite Univ, INSERM, UMR S976, Paris, France

[9] St Louis Lariboisiere Hosp Grp, AP HP, Dept Infect Dis, Paris, France

[10] French Natl Publ Hlth Agcy, Sante Publ France, F-94415 St Maurice, France

来源：

EUROSURVEILLANCE | 2023年 / 28卷 / 37期

关键词：

STRAIN;

D O I：

10.2807/1560-7917.ES.2023.28.37.2300456

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report two extensively drug-resistant (XDR) Neisseria gonorrhoeae (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, the mosaic penA-60.001 which caused ceftriaxone resistance in the internationally spreading FC428 clone, and the A2059G mutation in the 23S rRNA gene. The NG isolates F93 and F94 were related to XDR isolates detected in Austria and the United Kingdom in 2022.

引用

页数：5

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