Low seroprotection against diphtheria and tetanus in Lao adolescents

被引：3

作者：

Vantava, Sonephet ^{[1
]}

Hefele, Lisa ^{[2
]}

Virachith, Siriphone ^{[3
]}

Vannachone, Souphaphone ^{[1
]}

Khounvisith, Vilaysone ^{[3
]}

Nouanthong, Phonethipsavanh ^{[3
]}

Hubschen, Judith M. ^{[2
]}

Sayasone, Somphou ^{[1
]}

Black, Antony P. ^{[3
]}

机构：

[1] Lao Trop & Publ Hlth Inst, Minist Hlth, Viangchan, Laos

[2] Luxembourg Inst Hlth, Dept Infect & Immun, Grand, France

[3] Inst Pasteur du Laos, Lao Lux Lab, Viangchan, Laos

来源：

TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2023年 / 28卷 / 06期

关键词：

diphtheria; Laos; seroprevalence; tetanus; vaccination; SEROPREVALENCE;

D O I：

10.1111/tmi.13882

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

ObjectivesThere is currently no booster diphtheria or tetanus vaccine for Lao children before adolescence, despite international recommendations. We investigated seroprotection against diphtheria and tetanus among Lao adolescents. MethodsSeven hundred seventy-nine serum samples were tested for anti-diphtheria and anti-tetanus antibodies. ResultsOverall, 25.8% of the adolescents had antibody titers corresponding to protection against diphtheria and 30.9% to sufficient immunity against tetanus. Female participants >16 years were more likely to be protected against diphtheria (p < 0.001) and tetanus (p < 0.029). ConclusionLow protection against diphtheria and tetanus, possibly due to low vaccination coverage or antibody waning, suggests booster doses are warranted before adolescence.

引用

页码：501 / 506

页数：6

共 23 条

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