Recent Developments in Biopolymer-Based Hydrogels for Tissue Engineering Applications

被引：62

作者：

Hama, Rikako ^{[1
,2
]}

Ulziibayar, Anudari ^{[1
]}

Reinhardt, James W. ^{[1
]}

Watanabe, Tatsuya ^{[1
]}

Kelly, John ^{[1
]}

Shinoka, Toshiharu ^{[1
,3
,4
]}

机构：

[1] Nationwide Childrens Hosp, Abigail Wexner Res Inst, Ctr Regenerat Med, 700 Childrens Dr, Columbus, OH 43205 USA

[2] Tokyo Univ Agr & Technol, Grad Sch Engn, Dept Biotechnol & Life Sci, 2-24-16 Naka Cho, Koganei 1848588, Japan

[3] Nationwide Childrens Hosp, Heart Ctr, Dept Cardiothorac Surg, 700 Childrens Dr, Columbus, OH 43205 USA

[4] Ohio State Univ, Dept Surg, Cardiovasc Tissue Engn Program, Columbus, OH 43210 USA

来源：

BIOMOLECULES | 2023年 / 13卷 / 02期

关键词：

tissue engineering; hydrogel; drug delivery system (DDS); biodegradation; silk fibroin; collagen; elastin; chitosan; proteoglycan; METHACRYLOYL GELMA HYDROGELS; IN-VITRO CHARACTERIZATION; CROSS-LINKING; MECHANICAL-PROPERTIES; CONTROLLED-RELEASE; SKIN REGENERATION; GELATIN; CHITOSAN; COLLAGEN; FIBRIN;

D O I：

10.3390/biom13020280

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogels are being investigated for their application in inducing the regeneration of various tissues, and suitable conditions for each tissue are becoming more apparent. Conditions such as the mechanical properties, degradation period, degradation mechanism, and cell affinity can be tailored by changing the molecular structure, especially in the case of polymers. Furthermore, many high-functional hydrogels with drug delivery systems (DDSs), in which drugs or bioactive substances are contained in controlled hydrogels, have been reported. This review focuses on the molecular design and function of biopolymer-based hydrogels and introduces recent developments in functional hydrogels for clinical applications.

引用

页数：16

共 95 条

[71] Silk fibroin-based vascular repairing sheet with angiogenic-promoting activity of SVVYGLR peptide regenerated the damaged vascular in rats [J].