Anterior cruciate ligament tear increases the risk of venous thromboembolism: a population-based cohort study

被引:0
作者
Xiong, Yilin [1 ]
Li, Xiaoxiao [2 ,3 ,4 ]
Lei, Guanghua [1 ,2 ,3 ,4 ]
Zeng, Chao [1 ,2 ,3 ,4 ]
Wei, Jie [2 ,3 ,4 ,5 ]
Ding, Xiang [1 ]
Li, Hui [1 ]
机构
[1] Cent South Univ, Xiangya Hosp, Dept Orthopaed, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China
[2] Hunan Key Lab Joint Degenerat & Injury, Changsha, Hunan, Peoples R China
[3] Hunan Engn Res Ctr Osteoarthrit, Changsha, Hunan, Peoples R China
[4] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China
[5] Cent South Univ, Xiangya Hosp, Hlth Management Ctr, Changsha, Hunan, Peoples R China
基金
中国国家自然科学基金;
关键词
Anterior cruciate ligament; Tear; Venous thromboembolism; Deep vein thrombosis; Pulmonary embolism; Risk; DEEP-VEIN THROMBOSIS; IMPROVEMENT NETWORK THIN; PULMONARY-EMBOLISM; RECONSTRUCTION; KNEE; EPIDEMIOLOGY; INJURIES; THROMBOPROPHYLAXIS; COMPLICATIONS; PROPHYLAXIS;
D O I
10.1007/s00167-022-07097-x
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Purpose Previous studies highlighted an increased risk of venous thromboembolism (VTE) among patients with anterior cruciate ligament reconstruction (ACLR); however, the risk for those with ACL tear but without undergoing ACLR has not been reported yet. The aim of this study was to evaluate the risk of VTE among ACL tear individuals with or without ACLR derived from the general population. Methods A cohort study was conducted using data from the IQVIA Medical Research Database of the United Kingdom. Up to five non-ACL tear individuals (n = 22,235) were matched to each case of ACL tear (n = 4474) by age, sex, body mass index and entry-time. The relation of ACL tear to VTE [pulmonary embolism (PE) and deep vein thrombosis (DVT)] was examined using a multivariable Cox proportional hazard model. A sub-cohort analysis, in which the ACL tear individuals were stratified into those with ACLR and those without ACLR, was also conducted. Results VTE developed in 13 individuals with ACL tear and nine individuals without ACL tear (incidence rates: 3.1 vs. 0.4/1000 person-years), with multivariable-adjusted hazard ratio (HR) being 6.59 (95% CI 2.28-19.08) in 1-year follow-up. For ACL tear individuals with ACLR, the HR was 11.44 (95% CI 2.71-48.28), and for those without ACLR, the HR was 6.02 (95% CI 1.44-24.25), compared with individuals without ACL tear. Conclusion This large-sample population-based cohort study provides the first evidence on an increased risk of VTE in ACL tear individuals regardless of subsequent ACLR, which supports the necessity for monitoring venous-thromboembolic complications in the target population, including those without ACLR.
引用
收藏
页码:1805 / 1814
页数:10
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