Palladium/NBE-Catalyzed Regioselective C-H Silylation: Access to Divergent Silicon-Containing Indoles

被引：5

作者：

Li, Wenguang ^{[1
]}

Cao, Man ^{[1
]}

Zhang, Chunyan ^{[1
]}

Shi, Shukui ^{[1
]}

Liu, Juan ^{[1
]}

Li, Wentao ^{[1
]}

Zhang, Xu ^{[1
]}

Yu, Yongqi ^{[1
]}

Li, Ting ^{[1
]}

机构：

[1] Nanyang Normal Univ, Coll Chem & Pharmaceut Engn, Nanyang 473061, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; ARYL IODIDES; INTERMOLECULAR SILYLATION; EFFICIENT SYNTHESIS; BOND; FUNCTIONALIZATION; CASCADE; TRIFLUOROETHYLATION; HYDROSILYLATION; GERMANYLATION;

D O I：

10.1021/acs.orglett.3c04109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium/norbornene (NBE)-catalyzed regioselective C-H silylation of free NH-indoles is reported. This protocol uses Pd(OAc)(2) as the catalyst and Cu(OAc)(2) as the oxidant, and the reaction relies on the control of NBE as a switch. The reaction tolerates various functional groups, and a series of silicon-containing indoles were directly synthesized in 30%-94% yields.

引用

页码：1143 / 1147

页数：5

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