Sequential In Situ-Formed Kukhtin-Ramirez Adduct and P(NMe2)3-Catalyzed O-Phosphination of α-Dicarbonyls with P(O)-H

被引：11

作者：

Huang, Yuanyuan ^{[1
]}

Wang, Nan ^{[1
]}

Wu, Zheng-Guang ^{[1
]}

Wu, Xinxing ^{[1
]}

Wang, Mengke ^{[1
]}

Huang, Weichun ^{[1
]}

Zi, You ^{[1
]}

机构：

[1] Nantong Univ, Sch Chem & Chem Engn, Nantong 226019, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 42期

基金：

中国国家自然科学基金;

关键词：

REDUCTIVE 1+4 ANNULATION; PHOSPHA-BROOK REARRANGEMENT; DIASTEREOSELECTIVE SYNTHESIS; KETO ESTERS; INTRAMOLECULAR CYCLIZATION; EFFICIENT SYNTHESIS; QUINONE METHIDES; FACILE SYNTHESES; DERIVATIVES; CONDENSATION;

D O I：

10.1021/acs.orglett.3c02563

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

O-Phosphination of alpha-dicarbonyls via sequential in situ formation of a Kukhtin-Ramirez adduct and a P(NMe2)(3)-catalyzed process has been exploited for the synthesis of alpha-phosphoryloxy carbonyls. A range of P(O)-H derivatives, including diarylphosphine oxides, arylphosphinates, and phosphinates, are competent candidates to be introduced into the alpha-dicarbonyls in this transformation, and various alpha-phosphoryloxy carbonyls are obtained. This approach possesses advantages of mild conditions, simple operations, atom economy, high efficiency, and gram-scale synthesis, which make it promising in the synthesis toolbox.

引用

页码：7595 / 7600

页数：6

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