Lycii Fructus, a medicine food homology material, attenuates retinal damage in sodium iodate-induced retinal degeneration mice and inhibits oxidation-induced apoptosis of Muller cells via regulating Nrf2-HO1 signaling pathway

被引：1

作者：

Cao, Cheng ^{[1
]}

Lu, Yunqing ^{[1
]}

Li, Bing ^{[1
]}

Chen, Yang ^{[1
]}

Xu, Pan ^{[1
]}

Liu, Mengqiu ^{[1
]}

Zhu, Ziqiang ^{[1
]}

Yuan, Lei ^{[1
]}

Guo, Sheng ^{[1
,2
]}

Kang, Hongjie ^{[2
]}

Duan, Jin-ao ^{[1
]}

Zhu, Yue ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Natl & Local Collaborat Engn Ctr Chinese Med Resou, Jiangsu Collaborat Innovat Ctr Chinese Med Resourc, Jiangsu Prov Key Lab High Technol Res, Nanjing 210023, Peoples R China

[2] Ning Xia Innovat Ctr Wolfberry, Yinchuan 750000, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2023年 / 108卷

基金：

中国国家自然科学基金;

关键词：

Lycii Fructus; Muller cells; Retina; Age-related macular degeneration; Oxidation; BARBARUM POLYSACCHARIDES; MACULAR DEGENERATION; AUTOPHAGY; PIGMENT; STRESS; RPE;

D O I：

10.1016/j.jff.2023.105756

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Lycii Fructus (LF) is a medicinal-edible homology material frequently used for treating age-related macular degeneration (AMD) in Chinese medicine. Abundant of literatures verified the retina protection effect of LF on AMD-like animal models. However, previous studies on LF attenuating retinal damage mainly focused on its protection effect on pigment epithelial cells and optic ganglion cells while few reports on Muller cells. In the current study, we found that LF extracts attenuated oxidation damages and inhibited cell apoptosis of retina on a mouse retinal injury model induced by sodium iodate. LF extracts also increased expressions of Muller cell biomarker glutamine synthetase of eyeballs of model mice, which indicated that LF extract protected Muller cell from oxidation injury induced by sodium iodate. In Muller cell MIO-M1 cultures, LF also significantly inhibited cellular apoptosis induced by NaIO3 by regulating Nrf2/HO-1 signaling pathway and the aqueous extracts exerted better active tendency than ethanol extracts. These data implied that the antioxidant effect of LF on protecting Muller cell might contribute to its retina repair function, thereby providing more scientific evidences for the development of LF as an alternative therapy or preventive measures for AMD.

引用

页数：11

共 16 条

[1] Dietary Wolfberry Supplementation Enhances the Protective Effect of Flu Vaccine against Influenza Challenge in Aged Mice [J].