Interactive effects of locus coeruleus structure and catecholamine synthesis capacity on cognitive function

被引：5

作者：

Chen, Hsiang-Yu ^{[1
]}

Parent, Jourdan H. ^{[1
]}

Ciampa, Claire J. ^{[1
]}

Dahl, Martin J. ^{[2
,3
]}

Haemmerer, Dorothea ^{[4
]}

Maass, Anne ^{[5
]}

Winer, Joseph R. ^{[6
]}

Yakupov, Renat ^{[5
]}

Inglis, Ben ^{[7
]}

Betts, Matthew J. ^{[5
,8
,9
]}

Berry, Anne S. ^{[1
,10
]}

机构：

[1] Brandeis Univ, Dept Psychol, Waltham, MA 02453 USA

[2] Max Planck Inst Human Dev, Ctr Lifespan Psychol, Berlin, Germany

[3] Univ Southern Calif, USC Leonard Davis Sch Gerontol, Los Angeles, CA USA

[4] Univ Innsbruck, Psychol Inst, Innsbruck, Austria

[5] Deutsch Zentrum Neurodegenerat Erkrankungen, Magdeburg, Germany

[6] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA USA

[7] Univ Calif Berkeley, Henry H Wheeler Jr Brain Imaging Ctr, Berkeley, CA USA

[8] Otto Von Guericke Univ, Inst Cognit Neurol & Dementia Res, Magdeburg, Germany

[9] Otto von Guericke Univ, Ctr Behav Brain Sci, Magdeburg, Germany

[10] Lawrence Berkeley Natl Lab, Berkeley, CA USA

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2023年 / 15卷

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

locus coeruleus; catecholamine synthesis capacity; structural magnetic resonance imaging; positron emission tomography; partial least squares correlation; PARKINSONS-DISEASE; CERULEUS NEURONS; MRI CONTRAST; HUMAN BRAIN; AGE; SYSTEM; DYSFUNCTION; PROJECTIONS; MECHANISMS; DEPRESSION;

D O I：

10.3389/fnagi.2023.1236335

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

BackgroundThe locus coeruleus (LC) produces catecholamines (norepinephrine and dopamine) and is implicated in a broad range of cognitive functions including attention and executive function. Recent advancements in magnetic resonance imaging (MRI) approaches allow for the visualization and quantification of LC structure. Human research focused on the LC has since exploded given the LC's role in cognition and relevance to current models of psychopathology and neurodegenerative disease. However, it is unclear to what extent LC structure reflects underlying catecholamine function, and how LC structure and neurochemical function are collectively associated with cognitive performance.MethodsA partial least squares correlation (PLSC) analysis was applied to 19 participants' LC structural MRI measures and catecholamine synthesis capacity measures assessed using [18F]Fluoro-m-tyrosine ([18F]FMT) positron emission tomography (PET).ResultsWe found no direct association between LC-MRI and LC-[18F]FMT measures for rostral, middle, or caudal portions of the LC. We found significant associations between LC neuroimaging measures and neuropsychological performance that were driven by rostral and middle portions of the LC, which is in line with LC cortical projection patterns. Specifically, associations with executive function and processing speed arose from contributions of both LC structure and interactions between LC structure and catecholamine synthesis capacity.ConclusionThese findings leave open the possibility that LC MRI and PET measures contribute unique information and suggest that their conjoint use may increase sensitivity to brain-behavior associations in small samples.

引用

页数：10

共 64 条

[1]

ACHESON AL, 1981, J NEUROSCI, V1, P493

[2] Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology [J].