Neuroimaging in Alzheimer's Disease for Early Diagnosis: A Comprehensive Review

被引:18
作者
Aramadaka, Saikumar [1 ]
Mannam, Raam [1 ]
Narayanan, Rajagopal Sankara [1 ]
Bansal, Arpit [1 ]
Yanamaladoddi, Vishnu R. [2 ]
Sarvepalli, Sai Suseel [1 ]
Vemula, Shree Laya [3 ]
机构
[1] Narayana Med Coll, Res, Nellore, India
[2] Narayana Med Coll & Hosp, Res, Nellore, India
[3] ACSR Govt Med Coll, Res, Nellore, India
关键词
fdg pet; early diagnosis; tau-protein; amyloid pet; structural mri; functional magnetic resonance imaging; neuroimaging; alzheimer's disease; MILD COGNITIVE IMPAIRMENT; POSITRON-EMISSION-TOMOGRAPHY; MOLECULAR-IMAGING PROBE; TAU-PATHOLOGY; AMYLOID DEPOSITION; FUNCTIONAL CONNECTIVITY; HIPPOCAMPAL VOLUME; GLUCOSE-METABOLISM; LEWY BODIES; HUMAN BRAIN;
D O I
10.7759/cureus.38544
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting roughly half of those over the age of 85. We briefly discussed the risk factors, epidemiology, and treatment options for AD. The development of therapeutic therapies operating very early in the disease cascade has been spurred by the realization that the disease process begins at least a decade or more before the manifestation of symptoms. Thus, the clinical significance of early diagnosis was emphasized. Using various keywords, a literature search was carried out using PubMed and other databases. For inclusion, pertinent articles were chosen and reviewed. This article has reviewed different neuroimaging techniques that are considered advanced tools to aid in establishing a diagnosis and highlighted the advantages as well as disadvantages of those techniques. Besides, the prevalence of several in vivo biomarkers aided in discriminating affected individuals from healthy controls in the early stages of the disease. Each imaging method has its advantages and disadvantages, hence no single imaging approach can be the optimum modality for diagnosis. This article also commented on a better approach to using these techniques to increase the likelihood of an early diagnosis.
引用
收藏
页数:11
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