Iridium-catalysed reductive allylic amination of α,β-unsaturated aldehydes

被引：4

作者：

Liu, Liang ^{[1
]}

Luo, Renshi ^{[2
]}

Tong, Jinghui ^{[1
]}

Liao, Jianhua ^{[1
]}

机构：

[1] Gannan Med Univ, Sch Pharm, Ganzhou 341000, Jiangxi, Peoples R China

[2] Shaoguan Univ, Coll Chem & Environm Engn, Shaoguan 512005, Guangdong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

BAYLIS-HILLMAN CARBONATES; C-H AMINATION; ENANTIOSELECTIVE SYNTHESIS; TRIFLUOROMETHYL GROUP; PALLADIUM; AMINES; ALCOHOLS; ACID; EFFICIENT; HYDROAMINATION;

D O I：

10.1039/d3ob01753b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Allylic amination is a powerful tool for constructing N-allylic amines widely found in bioactive molecules. Generally, allylic alcohols and unsaturated hydrocarbons have been considered for allylic amination reactions to minimize waste production. Herein, we present an iridium-catalysed method for reductive allylic amination of alpha,beta-unsaturated aldehydes with amines to afford N-allylic amines under air conditions. This protocol is demonstrated to provide products from many substrates (41 examples) in moderate-to-excellent yields. This synthetic methodology is also highlighted by the synthesis of drug molecules, optically pure products, as well as scale-up experiments.

引用

页码：585 / 589

页数：5

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