The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma

被引：4
作者：
Giansante, Valentina [1 ]
Stati, Gianmarco [1 ]
Sancilio, Silvia [1 ]
Guerra, Emanuela [2 ,3 ]
Alberti, Saverio [4 ]
Di Pietro, Roberta [1 ,5 ]
Hoheisel, Joerg D.
机构：
[1] G Annunzio Univ Chieti Pescara, Dept Med & Aging Sci, Sect Biomorphol, I-66100 Chieti, Italy
[2] G Annunzio Univ Chieti Pescara, Ctr Adv Studies & Technol CAST, Lab Canc Pathol, I-66100 Chieti, Italy
[3] G Annunzio Univ Chieti Pescara, Dept Med Oral & Biotechnol Sci, I-66100 Chieti, Italy
[4] Univ Messina, Dept Biomed Sci, Unit Med Genet, I-98122 Messina, Italy
[5] Temple Univ, Sbarro Inst Canc Res & Mol Med, Coll Sci & Technol, Ctr Biotechnol,Dept Biol, Philadelphia, PA 19122 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 16期
关键词：
pancreatic cancer; necroptosis; tumor microenvironment; cell death; PAPILLARY MUCINOUS NEOPLASMS; CELL-DEATH; INTRAEPITHELIAL NEOPLASIA; EXTRACELLULAR VESICLES; CYSTIC NEOPLASMS; GNAS MUTATIONS; CANCER; ACTIVATION; CARCINOMA; DISTINCT;
D O I：
10.3390/ijms241612633
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic cancer (PC) is the seventh leading cause of cancer-related death. PC incidence has continued to increase by about 1% each year in both men and women. Although the 5-year relative survival rate of PC has increased from 3% to 12%, it is still the lowest among cancers. Hence, novel therapeutic strategies are urgently needed. Challenges in PC-targeted therapeutic strategies stem from the high PC heterogeneity and from the poorly understood interplay between cancer cells and the surrounding microenvironment. Signaling pathways that drive PC cell growth have been the subject of intense scrutiny and interest has been attracted by necroptosis, a distinct type of programmed cell death. In this review, we provide a historical background on necroptosis and a detailed analysis of the ongoing debate on the role of necroptosis in PC malignant progression.
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页数：16
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