Association of Adiponectin-Leptin Ratio and HOMA-IR in Obese Patients with and without Type 2 Diabetes Mellitus: A Cross-sectional Study

被引:0
作者
Saini, Mandeep Singh [1 ]
Kaur, Jaskiran [2 ]
Sabharwal, Ravjit Kaur [1 ]
Kukreja, Sahiba [2 ]
Kaur, Jaswinder [3 ]
Samal, Indira R. [1 ]
机构
[1] Punjab Inst Med Sci, Dept Biochem, Garha Rd, Jalandhar 144006, Punjab, India
[2] Sri Guru Ram Das Inst Med Sci & Res, Dept Biochem, Amritsar, Punjab, India
[3] Punjab Inst Med Sci, Dept Med, Jalandhar, Punjab, India
关键词
Adipose tissue; Glycated haemoglobin; Homeostatic model assessment of insulin resistance; Insulin levels; INSULIN-RESISTANCE; BODY-WEIGHT; RISK;
D O I
10.7860/JCDR/2023/65235.18270
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Obesity is one of the leading causes of morbidity and mortality due to associated risk factors, including Type 2 Diabetes Mellitus (T2DM). Obese and diabetic patients have lower amounts of adiponectin. Leptin, a hormone released by adipocytes that controls hunger, is crucial in the emergence of obesity. Furthermore, it has been claimed that the Adiponectin/ Leptin Ratio (ALR) correlates with Insulin Resistance (IR) better than adiponectin or leptin alone. Aim: To evaluate adiponectin, leptin, and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) in obese subjects with and without T2DM and compare the variations, if any, from the normal subjects. Materials and Methods: This hospital-based, cross-sectional study was carried out at Sri Guru Ram Das (SGRD) University of Health Sciences, Amritsar, and Punjab Institute of Medical Sciences (PIMS), Jalandhar from January 2020 to December 2022. A total of 125 subjects of either gender aged above 18 years, visiting the medicine Outpatient Department (OPD) of PIMS, Jalandhar, were included in the study. Among them, 25 healthy volunteers served as controls. Serum levels of Adiponectin, Leptin, and Insulin were estimated using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The data obtained were statistically analysed using one-way Analysis of Variance (ANOVA) test (with Bonferroni post-hoc). Results: A total of 125 participants were analysed in the present study, with 50 being obese with T2DM (mean age: 50.22 +/- 8.6 years), 50 being obese without T2DM (mean age: 46.9 +/- 9.8 years), and 25 being non obese non diabetic individuals (controls) (mean age: 42.8 +/- 9.09 years). A higher number of females 78 (62.4%) reported to the OPD compared to males 47 (37.6%). Although no statistical significance was found, there was a considerable decrease in adiponectin levels in obese and obese with T2DM subjects. Moreover, the leptin levels and HOMA-IR were increased in obese and obese with T2DM subjects compared to the control subjects. Conclusion: ALR may be used as a clinical marker for assessing the morbidity due to obesity and in T2DM subjects. Moreover, lifestyle modifications can be targeted to prevent IR.
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页码:BC1 / BC4
页数:4
相关论文
共 40 条
[1]   Amelioration of Insulin, Leptin and Adiponectin Levels in Experimental Metabolic Syndrome Model by Some Drugs [J].
Al-Rasheed, N. M. ;
Abdelkarem, H. M. ;
Fadda, L. M. ;
Mohamed, A. M. ;
Al-Rasheed, N. M. ;
Bassiouni, Y. ;
Ali, H. M. ;
Gafeer, H. .
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 78 (06) :701-707
[2]  
Albarracin M.L.G., 2020, DOAJ, V26, P93, DOI DOI 10.1159/000510521
[3]  
[Anonymous], 2016, Int J Clin Biomed Res
[4]   Polymorphism rs3123554 in the cannabinoid receptor gene type 2 (CNR2) reveals effects on body weight and insulin resistance in obese subjects [J].
Antonio de Luis, Daniel ;
Izaola, Olatz ;
Primo, David ;
de la Fuente, Beatriz ;
Alter, Rocio .
ENDOCRINOLOGIA DIABETES Y NUTRICION, 2017, 64 (08) :440-445
[5]  
Ayman SS, Med J Cairo Univ., V87, P4227
[6]   Homeostatic model assessment of insulin resistance as a predictor of metabolic syndrome: Consequences of obesity in children and adolescents [J].
Barseem, Naglaa Fathy ;
Helwa, Mohamed Ahmed .
EGYPTIAN PEDIATRIC ASSOCIATION GAZETTE, 2015, 63 (01) :19-24
[7]   Improving Adiponectin Levels in Individuals With Diabetes and Obesity: Insights From Look AHEAD [J].
Belalcazar, L. Maria ;
Lang, Wei ;
Haffner, Steven M. ;
Schwenke, Dawn C. ;
Kriska, Andrea ;
Balasubramanyam, Ashok ;
Hoogeveen, Ron C. ;
Pi-Sunyer, F. Xavier ;
Tracy, Russell P. ;
Ballantyne, Christie M. .
DIABETES CARE, 2015, 38 (08) :1544-1550
[8]   Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study [J].
Bidulescu, Aurelian ;
Dinh, Paul C. ;
Sarwary, Shabir ;
Forsyth, Emily ;
Luetke, Maya C. ;
King, David B. ;
Liu, Jiankang ;
Davis, Sharon K. ;
Correa, Adolfo .
BMC ENDOCRINE DISORDERS, 2020, 20 (01)
[9]  
Bramante Carolyn T, 2017, Diabetes Spectr, V30, P237, DOI 10.2337/ds17-0030
[10]  
Burtis C.A., 1994, TIETZ TXB CLIN CHEM