Fasting and fasting mimicking diets in cancer prevention and therapy

被引：33

作者：

Blazevits, Olga ^{[1
]}

Di Tano, Maira ^{[2
,3
]}

Longo, Valter D. ^{[1
,4
,5
]}

机构：

[1] IFOM ETS, AIRC Inst Mol Oncol, Milan, Italy

[2] Weill Cornell Med, Dept Med, Div Endocrinol, New York, NY 10065 USA

[3] Weill Cornell Med, Meyer Canc Ctr, New York, NY 10065 USA

[4] Univ Southern Calif, Longev Inst, Davis Sch Gerontol, Los Angeles, CA 90089 USA

[5] Univ Southern Calif, Dept Biol Sci, Los Angeles, CA 90089 USA

来源：

TRENDS IN CANCER | 2023年 / 9卷 / 03期

基金：

美国国家卫生研究院;

关键词：

STRESS RESISTANCE; MOLECULAR-MECHANISMS; CALORIC RESTRICTION; STARVATION; ASCORBATE; REGENERATION; GEMCITABINE; PROTECTION; RESPONSES; HUMANS;

D O I：

10.1016/j.trecan.2022.12.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fasting mimicking diets (FMDs) are emerging as effective dietary interventions with the potential to improve healthspan and decrease the incidence of cancer and other age-related diseases. Unlike chronic dietary restrictions or wateronly fasting, FMDs represent safer and less challenging options for cancer patients. FMD cycles increase protection in healthy cells while sensitizing cancer cells to various therapies, partly by generating complex environments that promote differential stress resistance (DSR) and differential stress sensitization (DSS), respectively. More recent data indicate that FMD cycles enhance the efficacy of a range of drugs targeting different cancers in mice by stimulating antitumor immunity. Here, we report on the effects of FMD cycles on cancer prevention and treatment and the mechanisms implicated in these effects.

引用

页码：212 / 222

页数：11

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