Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites

被引:15
作者
Liu, Xinyuan [1 ]
Dun, Mengqian [1 ]
Jian, Tongtong [2 ]
Sun, Yuqing [1 ]
Wang, Mingyu [1 ]
Zhang, Guoying [2 ]
Ling, Jianya [1 ]
机构
[1] Shandong Univ, State Key Lab Microbial Technol, Qingdao, SD, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Jinan, SD, Peoples R China
基金
中国国家自然科学基金;
关键词
T2DM; C; militaris; gut microbiota; 16S rDNA; metabolomics; pathway; INFLAMMATION; PROFILES;
D O I
10.3389/fphar.2023.1134429
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Cordyceps militaris, which has many potential medicinal properties, has rarely been reported to alleviate type 2 diabetes mellitus (T2DM). Methods: The effects of C. militaris extracts (CE) and cordycepin (CCS) on high-fat diet and streptozotocin (STZ) induced T2DM mice were analysed by gut microbiome and metabolomics methods in this study. Results: The results demonstrated that glucose and lipid metabolism parameters, oxidative stress biomarkers and inflammation cytokines were down-regulated in the CCS and CE groups. A comparative analysis of the fecal samples from mice in the model and experimental groups showed that experimental groups resulted in a higher abundance of Firmicutes/Bacteroidetes. Conclusion: This study provides evidence that C. militaris can be used as a food supplement to relieve T2DM, which provides a promising prospect for new functional food in it.
引用
收藏
页数:14
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