A TREM2 antibody energizes microglia

被引：7

作者：

Zhao, Na ^{[1
]}

Bu, Guojun ^{[2
]}

机构：

[1] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[2] SciNeuro Pharmaceut, Rockville, MD 20850 USA

来源：

NATURE NEUROSCIENCE | 2023年 / 26卷 / 03期

关键词：

D O I：

10.1038/s41593-023-01265-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Loss-of-function variants of TREM2 increase risk for Alzheimer's disease. A new study presents a therapeutic candidate - ATV:TREM2, a TREM2-activating antibody engineered with a transferrin receptor binding site to facilitate blood-to-brain transport. Treatment of a mouse model of Alzheimer's disease with ATV:TREM2 improved energy metabolism and microglial function.

引用

页码：366 / 368

页数：3

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