The Management of Hypercholesterolemia in Patients with Neuromuscular Disorder

被引：3
作者：
Loh, Wann Jia [1 ,2 ,3 ,4 ]
Watts, Gerald F. [1 ,2 ]
机构：
[1] Univ Western Australia, Sch Med, Perth, WA 6001, Australia
[2] Royal Perth Hosp, Dept Cardiol & Internal Med, Cardiometab Serv, Perth, Australia
[3] Changi Gen Hosp, Dept Endocrinol, Singapore, Singapore
[4] Duke NUS Med Sch, Singapore, Singapore
来源：
CURRENT ATHEROSCLEROSIS REPORTS | 2023年 / 25卷 / 02期
关键词：
Hypercholesterolemia; Neuromuscular disorder; Myasthenia gravis; Statin safety; Statin myotoxicity; Immune-mediated necrotizing myopathy; ASCVD RISK REDUCTION; CARDIOVASCULAR-DISEASE; CEREBROTENDINOUS XANTHOMATOSIS; SCIENTIFIC STATEMENT; METABOLIC SYNDROME; DRUG-INTERACTIONS; STATINS; DERMATOMYOSITIS; DYSLIPIDEMIA; PREVENTION;
D O I：
10.1007/s11883-022-01077-9
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Purpose of Review We describe and discuss the safety of statins and non-statin drugs in neuromuscular disorders (NMDs). We also propose a pragmatic model of care for the management of such cases.Recent Findings Patients with both NMD and hypercholesterolemia may be particularly disadvantaged owing to the toxic effects of cholesterol-lowering therapy and the inability to take medication. Specifically, the management of hypercholesterolemia in patients with NMD is complicated by the increased risk of statin-related myotoxicity and concerns that statins may aggravate or possibly induce the onset of a specific NMD. The most severe form of statin-related myotoxicity is immune-mediated necrotizing myopathy.Summary Management of hypercholesterolemia in patients with NMDs include treating modifiable factors, consideration of toxicity risk of statin, use of non-statin lipid lowering agents, noting possible drug interactions, and careful monitoring.
引用
收藏
页码：43 / 53
页数：11
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