Technical note: In silico benchmarking of the linear energy transfer-based functionalities for carbon ion beams in a commercial treatment planning system

被引：8

作者：

Schafasand, Mansure ^{[1
,2
,5
]}

Resch, Andreas Franz ^{[1
,2
]}

Traneus, Erik ^{[3
]}

Glimelius, Lars ^{[3
]}

Fossati, Piero ^{[1
,4
]}

Stock, Markus ^{[1
,4
]}

Gora, Joanna ^{[1
]}

Georg, Dietmar ^{[2
]}

Carlino, Antonio ^{[1
]}

机构：

[1] MedAustron Ion Therapy Ctr, Wiener Neustadt, Austria

[2] Med Univ Vienna, Dept Radiat Oncol, Vienna, Austria

[3] RaySearch Labs AB, Stockholm, Sweden

[4] Karl Landsteiner Univ Hlth Sci, Dept Oncol, Krems An Der Donau, Austria

[5] Med Austron Ion Therapy Ctr, Marie Curie Str 5, A-2700 Wiener Neustadt, Austria

来源：

MEDICAL PHYSICS | 2023年 / 50卷 / 03期

关键词：

carbon ion radiotherapy; GATE; Geant4 Monte Carlo simulations; linear energy transfer; THERAPY; RBE; GEANT4; MODELS; FLUKA; VIVO;

D O I：

10.1002/mp.16174

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

BackgroundThe increasing number of studies dealing with linear energy transfer (LET)-based evaluation and optimization in the field of carbon ion radiotherapy (CIRT) indicates the rising demand for LET implementation in commercial treatment planning systems (TPS). Benchmarking studies could play a key role in detecting (and thus preventing) computation errors prior implementing such functionalities in a TPS. PurposeThis in silico study was conducted to benchmark the following two LET-related functionalities in a commercial TPS against Monte Carlo simulations: (1) dose averaged LET (LETd) scoring and (2) physical dose filtration based on LET for future LET-based treatment plan evaluation and optimization studies. MethodsThe LETd scoring and LET-based dose filtering (in which the deposited dose can be separated into the dose below and above the user specified LET threshold) functionalities for carbon ions in the research version RayStation (RS) 9A-IonPG TPS (RaySearch Laboratories, Sweden) were benchmarked against GATE/Geant4 simulations. Pristine Bragg peaks (BPs) and cuboid targets, positioned at different depths in a homogeneous water phantom and a setup with heterogeneity were used for this study. ResultsFor all setups (homogeneous and heterogeneous), the mean absolute (and relative) LETd difference was less than 1 keV/mu$\umu$m (3.5%) in the plateau and target and less than 2 keV/mu$\umu$m (8.3%) in the fragmentation tail. The maximum local differences were 4 and 6 keV/mu$\umu$m, respectively. The mean absolute (and relative) physical dose differences for both low- and high-LET doses were less than 1 cGy (1.5%) in the plateau, target and tail with a maximum absolute difference of 2 cGy. ConclusionsNo computation error was found in the tested functionalities except for LETd in lateral direction outside the target, showing the limitation of the implemented monochrome model in the tested TPS version.

引用

页码：1871 / 1878

页数：8

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