Galectin-1 in Pancreatic Ductal Adenocarcinoma: Bridging Tumor Biology, Immune Evasion, and Therapeutic Opportunities

被引：8

作者：

Bogut, Ana ^{[1
]}

Stojanovic, Bojan ^{[2
,3
]}

Jovanovic, Marina ^{[4
]}

Dimitrijevic Stojanovic, Milica ^{[5
]}

Gajovic, Nevena ^{[6
]}

Stojanovic, Bojana S. ^{[7
]}

Balovic, Goran ^{[2
]}

Jovanovic, Milan ^{[8
]}

Lazovic, Aleksandar ^{[3
]}

Mirovic, Milos ^{[9
]}

Jurisevic, Milena ^{[10
]}

Jovanovic, Ivan ^{[6
]}

Mladenovic, Violeta ^{[4
]}

机构：

[1] City Med Emergency Dept, Belgrade 11000, Serbia

[2] Univ Kragujevac, Fac Med Sci, Dept Surg, Kragujevac 34000, Serbia

[3] Univ Clin Ctr Kragujevac, Dept Gen Surg, Kragujevac 34000, Serbia

[4] Univ Kragujevac, Fac Med Sci, Dept Internal Med, Kragujevac 34000, Serbia

[5] Univ Kragujevac, Fac Med Sci, Dept Pathol, Kragujevac 34000, Serbia

[6] Univ Kragujevac, Fac Med Sci, Ctr Mol Med & Stem Cell Res, Kragujevac 34000, Serbia

[7] Univ Kragujevac, Fac Med Sci, Dept Pathophysiol, Kragujavac 34000, Serbia

[8] Mil Med Acad, Dept Abdominal Surg, Belgrade 11000, Serbia

[9] Gen Hosp Kotor, Dept Surg, Kotor 85330, Montenegro

[10] Univ Kragujevac, Fac Med Sci, Dept Clin Pharm, Kragujevac 34000, Serbia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 21期

关键词：

pancreatic ductal adenocarcinoma; Galectin-1; tumor microenvironment; angiogenesis; immune modulation; LONG-TERM SURVIVAL; T-CELL IMMUNITY; STELLATE CELLS; DOWN-REGULATION; IN-VITRO; CANCER; EXPRESSION; PROMOTES; PROLIFERATION; MICROENVIRONMENT;

D O I：

10.3390/ijms242115500

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the most challenging malignancies to treat, with a complex interplay of molecular pathways contributing to its aggressive nature. Galectin-1 (Gal-1), a member of the galectin family, has emerged as a pivotal player in the PDAC microenvironment, influencing various aspects from tumor growth and angiogenesis to immune modulation. This review provides a comprehensive overview of the multifaceted role of Galectin-1 in PDAC. We delve into its contributions to tumor stroma remodeling, angiogenesis, metabolic reprogramming, and potential implications for therapeutic interventions. The challenges associated with targeting Gal-1 are discussed, given its pleiotropic functions and complexities in different cellular conditions. Additionally, the promising prospects of Gal-1 inhibition, including the utilization of nanotechnology and theranostics, are highlighted. By integrating recent findings and shedding light on the intricacies of Gal-1's involvement in PDAC, this review aims to provide insights that could guide future research and therapeutic strategies.

引用

页数：29

共 162 条

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