Imbalanced clearance of Aβ peptide cause presynaptic plaque formation

被引：4

作者：

Fotuhi, Seyedeh Nahid ^{[1
]}

Khalaj-Kondori, Mohammad ^{[1
]}

机构：

[1] Univ Tabriz, Fac Nat Sci, Dept Anim Biol, Tabriz, Iran

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2024年 / 134卷 / 01期

关键词：

Alzheimer's disease; amyloid beta plaque; pathology; clearance; synapse; CEREBRAL AMYLOID ANGIOPATHY; ALZHEIMERS-DISEASE; ACCUMULATION; OLIGOMERS; PROTEIN; CELLS; DEPOSITION; INTEGRITY; SYNAPSES; DEMENTIA;

D O I：

10.1080/00207454.2022.2085099

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease is characterized by abnormal increase of A beta peptide which is likely as the result of imbalanced homeostasis of its production and clearance mechanisms. Here, we briefly review that the uncleaned extracellular A beta peptides are loaded into presynaptic neurons. The A beta oligomers desperately affect pre- and post-synapse neuron activity and turn into plaques inside the presynaptic neurons over the time passes.

引用

页码：66 / 70

页数：5

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