Imbalanced clearance of Aβ peptide cause presynaptic plaque formation

被引：4
|
作者：
Fotuhi, Seyedeh Nahid [1 ]
Khalaj-Kondori, Mohammad [1 ]
机构：
[1] Univ Tabriz, Fac Nat Sci, Dept Anim Biol, Tabriz, Iran
来源：
INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2024年 / 134卷 / 01期
关键词：
Alzheimer's disease; amyloid beta plaque; pathology; clearance; synapse; CEREBRAL AMYLOID ANGIOPATHY; ALZHEIMERS-DISEASE; ACCUMULATION; OLIGOMERS; PROTEIN; CELLS; DEPOSITION; INTEGRITY; SYNAPSES; DEMENTIA;
D O I：
10.1080/00207454.2022.2085099
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease is characterized by abnormal increase of A beta peptide which is likely as the result of imbalanced homeostasis of its production and clearance mechanisms. Here, we briefly review that the uncleaned extracellular A beta peptides are loaded into presynaptic neurons. The A beta oligomers desperately affect pre- and post-synapse neuron activity and turn into plaques inside the presynaptic neurons over the time passes.
引用
收藏
页码：66 / 70
页数：5
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