Fruit Intake and Alzheimer's Disease: Results from Mendelian Randomization

被引：3

作者：

Liao, Wan-Zhe ^{[1
,2
,3
,5
]}

Zhu, X. F. ^{[1
,2
,3
]}

Xin, Q. ^{[1
,2
,4
]}

Mo, Y. T. ^{[1
,2
,4
]}

Wang, L. L. ^{[1
,2
,4
]}

He, X. P. ^{[1
,2
,4
]}

Guo, Xu-Guang ^{[1
,2
,3
,6
]}

机构：

[1] Guangzhou Med Univ, Guangdong Prov Clin Res Ctr Obstet & Gynecol, Guangdong Prov Key Lab Major Obstet Dis, Dept Clin Lab Med,Affiliated Hosp 3, Guangzhou 510150, Peoples R China

[2] Guangzhou Med Univ, King Med Sch Lab Med, Guangzhou Key Lab Clin Rapid Diag & Early Warning, Guangzhou 510000, Peoples R China

[3] Guangzhou Med Univ, Nanshan Coll, Guangzhou 511436, Peoples R China

[4] Guangzhou Med Univ, Dept Clin Med, Third Clin Sch, Guangzhou 511436, Peoples R China

[5] Guangzhou Med Univ, Nanshan Coll, Guangzhou, Peoples R China

[6] Guangzhou Med Univ, Dept Clin Lab Med, Affiliated Hosp 3, Guangzhou, Peoples R China

来源：

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE | 2024年 / 11卷 / 02期

关键词：

Fruit intake; Alzheimer's disease; two-sample mendelian Randomization; aging health; RISK; INSTRUMENTS; DIET; BIAS;

D O I：

10.14283/jpad.2024.31

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is the leading cause of dementia in old age, recognized as a global health priority. To explore causal effects of fresh fruit intake and dried fruit intake on AD liability, this study utilized GWAS from the UK Biobank and FinnGen to conduct Mendelian randomization (MR) analysis, and used inverse variance weighted (IVW), MR-Egger, and weighted median approaches for MR estimates, and visual inspections judged result stability. Results suggested little evidence of a potential causal relationship between fresh fruit intake and AD (OR=0.97, 95%CI=0.50-1.91, P=0.939), while significant, robust causality was indicated between dried fruit intake and AD (OR=4.09, 95%CI=2.07-8.10, P<0.001). Stability evaluations showed no heterogeneity or pleiotropy affecting interpretability and credibility of primary analyses. In conclusion, we strengthened evidence for positive causality from dried fruit intake to AD liability, with causality from fresh fruit intake on AD risk was not demonstrated.

引用

页码：445 / 452

页数：8

共 30 条

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