Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis

被引：42

作者：

Dejas, Leonie ^{[1
]}

Santoni, Karin ^{[2
]}

Meunier, Etienne ^{[2
]}

Lamkanfi, Mohamed ^{[1
,3
]}

机构：

[1] Univ Ghent, Dept Internal Med & Pediat, Lab Med Immunol, B-9000 Ghent, Belgium

[2] Univ Toulouse, Inst Pharmacol & Struct Biol, CNRS, F-31400 Toulouse, France

[3] Univ Ghent, Lab Med Immunol, C Heymanslaan 10, Med Res Bldg 2,MRB2, B-9000 Ghent, Belgium

来源：

SEMINARS IN IMMUNOLOGY | 2023年 / 70卷

基金：

欧洲研究理事会;

关键词：

Neutrophil; Apoptosis; Pyroptosis; Netosis; Cell death; Inflammation; Infection; DEPENDENT IL-1-BETA SECRETION; EXTRACELLULAR DNA TRAPS; NLRP3; INFLAMMASOME; GASDERMIN-D; CHROMATIN DECONDENSATION; ACTIVATION; CASPASE-11; RELEASE; BCL-2; PHAGOCYTOSIS;

D O I：

10.1016/j.smim.2023.101849

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils are among the most abundant immune cells, representing about 50%-70% of all circulating leu-kocytes in humans. Neutrophils rapidly infiltrate inflamed tissues and play an essential role in host defense against infections. They exert microbicidal activity through a variety of specialized effector mechanisms, including phagocytosis, production of reactive oxygen species, degranulation and release of secretory vesicles containing broad-spectrum antimicrobial factors. In addition to their homeostatic turnover by apoptosis, recent studies have revealed the mechanisms by which neutrophils undergo various forms of regulated cell death. In this review, we will discuss the different modes of regulated cell death that have been described in neutrophils, with a particular emphasis on the current understanding of neutrophil pyroptosis and its role in infections and autoinflammation.

引用

页数：9

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