Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia

被引：2

作者：

Vermeiren, Simon ^{[1
]}

Cabochette, Pauline ^{[1
]}

Dannawi, Maya ^{[1
]}

Desiderio, Simon ^{[1
]}

Jose, Alba SabateSan ^{[1
]}

Achouri, Younes ^{[2
]}

Kricha, Sadia ^{[1
]}

Sitte, Maren ^{[3
]}

Salinas-Riester, Gabriela ^{[3
]}

Vanhollebeke, Benoit ^{[1
]}

Brunet, Jean-Francois ^{[4
,5
,6
]}

Bellefroid, Eric J. ^{[1
]}

机构：

[1] Univ Libre Bruxelles, ULB Neurosci Inst, Dept Mol Biol, B-6041 Gosselies, Belgium

[2] Catholic Univ Louvain, Inst Duve, Transgenesis Platform, Brussels, Belgium

[3] Univ Med Ctr Goettingen UMG, NGS Integrat Genom, Dept Human Genet, D-37075 Gottingen, Germany

[4] PSL Res Univ, Inst Biol ENS IBENS, Inserm, CNRS,Ecole Normale Super, F-75005 Paris, France

[5] CNRS, Unite Mixte Rech 8197, F-75005 Paris, France

[6] INSERM, U1024, F-75005 Paris, France

来源：

ISCIENCE | 2023年 / 26卷 / 12期

关键词：

Bax-dependent apoptosis; visceral determinants; somatosensory ganglia; SENSORY NEURONS; TRANSCRIPTION FACTORS; GENE; DIFFERENTIATION; DEFICIENT; NEUROGENESIS; PROTEINS; DELETION; ABSENCE; FAMILY;

D O I：

10.1016/j.isci.2023.108364

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prdm12 is a transcriptional regulator essential for the emergence of the somatic nociceptive lineage durremain, however, poorly understood. Here, we report that the trigeminal and dorsal root ganglia hypoer, not sufficient to impose a complete fate switch in surviving somatosensory neurons. Mechanistically, our data reveal that Prdm12 is required from somatosensory neural precursors to early post-mitotic differentiating nociceptive neurons to repress Phox2a/b and that its repressive function is context dependent. Together, these findings reveal that besides its essential role in nociceptor survival during development, Prdm12 also promotes nociceptor fate via an additional mechanism, by preventing precursors from engaging into an alternate Phox2 driven visceral neuronal type differentiation program.

引用

页数：20

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