Evaluation of Prevalence of Hepatitis E Clinical Markers among Donors in Estonia

被引:1
作者
Kuznetsova, Tatiana [1 ]
Moor, Diana [2 ]
Khanirzayeva, Gulara [2 ]
Geller, Julia [1 ]
机构
[1] Natl Inst Hlth Dev, Dept Infect Dis Res, EE-11619 Tallinn, Estonia
[2] North Estonia Med Ctr Fdn, North Estonia Med Ctr, Blood Ctr, EE-13419 Tallinn, Estonia
来源
VIRUSES-BASEL | 2023年 / 15卷 / 10期
关键词
hepatitis E virus; seroprevalence; blood donor; E VIRUS-INFECTION; BLOOD-DONORS; DOMESTIC PIGS; SEROPREVALENCE; IGG; PERFORMANCE; ANTIBODIES; RNA;
D O I
10.3390/v15102118
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Hepatitis E virus (HEV) is now considered the most common cause of acute hepatitis worldwide. There are no published data about the prevalence of antibodies to HEV and RNA in donor sera in Estonia, and this precludes planning measures for preventing HEV proliferation through blood transfusion services. Here, were report data from an analysis of 1002 sera on the prevalence of anti-HEV IgG and IgM and the viral RNA. The antibodies were found in 48 donor sera (4.8%); of these, 40 (4%) harbored anti-HEV IgG, 15 (1.5%) contained anti-HEV IgM, and 7 donors had anti-HEV antibodies of both classes simultaneously. HEV RNA was not detected in any blood serum. Statistical associations of infection risk factors (gender, age, travel in the last six months, contact with pigs and/or wild boars in the last six months, consumption of thermally unprocessed/raw pork or boar meat, raw/unfiltered tap water or water from natural sources, unpasteurized farm dairy products, and unwashed berries and/or vegetables) were assessed. None of the listed factors were found to be associated with a higher or lower risk of anti-HEV antibody presence. At the same time, an increasing share of anti-HEV IgG carriers with age was found. The absence of HEV RNA in the analyzed donor plasma samples proves that HEV acute infection prevalence in Estonia does not exceed the average level of European countries. There is no urgent necessity to enter a requirement for a total screening of blood plasma for HEV RNA prevalence in Estonia.
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页数:11
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共 29 条
  • [1] Hepatitis E virus infection in Europe: surveillance and descriptive epidemiology of confirmed cases, 2005 to 2015
    Aspinall, E. J.
    Couturier, E.
    Faber, M.
    Said, B.
    Ijaz, S.
    Tavoschi, L.
    Takkinen, J.
    Adlhoch, C.
    [J]. EUROSURVEILLANCE, 2017, 22 (26): : 13 - 22
  • [2] Occurrence of hepatitis E virus RNA in plasma donations from Sweden, Germany and the United States
    Baylis, S. A.
    Gaertner, T.
    Nick, S.
    Ovemyr, J.
    Bluemel, J.
    [J]. VOX SANGUINIS, 2012, 103 (01) : 89 - 90
  • [3] Detection of Hepatitis A RNA, Hepatitis E RNA, Human Adenovirus F DNA, and Norovirus RNA in Fresh and Frozen Berry Products at Point of Retail in Ireland
    Bennett, Charlene
    Hunt, Kevin
    Butler, Francis
    Keaveney, Sinead
    Fanning, Seamus
    De Gascun, Cillian
    Coughlan, Suzie
    OGorman, Joanne
    [J]. FOOD AND ENVIRONMENTAL VIROLOGY, 2023, 15 (03) : 246 - 254
  • [4] Hepatitis E virus and blood transfusion safety
    Bi, Hao
    Yang, Ru
    Wu, Chunchen
    Xia, Jianbo
    [J]. EPIDEMIOLOGY AND INFECTION, 2020, 148
  • [5] Blood Donor Screening for Hepatitis E Virus in the European Union
    Boland, Fiona
    Martinez, Auxiliadora
    Pomeroy, Louise
    O'Flaherty, Niamh
    [J]. TRANSFUSION MEDICINE AND HEMOTHERAPY, 2019, 46 (02) : 95 - 103
  • [6] Hepatitis E virus IgG seroprevalence in HIV patients and blood donors, west-central Poland
    Bura, Maciej
    Lagiedo, Malgorzata
    Michalak, Michal
    Sikora, Jan
    Mozer-Lisewska, Iwona
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2017, 61 : 20 - 22
  • [7] Seroprevalence Study of Anti-HEV IgG among Different Adult Populations in Corsica, France, 2019
    Capai, Lisandru
    Masse, Shirley
    Gallian, Pierre
    Souty, Cecile
    Isnard, Christine
    Blanchon, Thierry
    Peres, Brigitte
    de Lamballerie, Xavier
    Charrel, Remi
    Falchi, Alessandra
    [J]. MICROORGANISMS, 2019, 7 (10)
  • [8] Hepatitis E Virus Seroprevalence among Adults, Germany
    Faber, Mirko S.
    Wenzel, Jurgen J.
    Jilg, Wolfgang
    Thamm, Michael
    Hoehle, Michael
    Stark, Klaus
    [J]. EMERGING INFECTIOUS DISEASES, 2012, 18 (10) : 1654 - 1657
  • [9] Molecular and serological infection marker screening in blood donors indicates high endemicity of hepatitis E virus in Poland
    Grabarczyk, Piotr
    Sulkowska, Ewa
    Gdowska, Jolanta
    Kopacz, Aneta
    Liszewski, Grzegorz
    Kubicka-Russel, Dorota
    Baylis, Sally A.
    Corman, Victor M.
    Nocen, Ewa
    Piotrowski, Dariusz
    Antoniewicz-Papis, Jolanta
    Letowska, Magdalena
    [J]. TRANSFUSION, 2018, 58 (05) : 1245 - 1253
  • [10] Molecular Characterization and Seroprevalence of Hepatitis E Virus in Inflammatory Bowel Disease Patients and Solid Organ Transplant Recipients
    Grigas, Juozas
    Montoya, Maria
    Simkute, Evelina
    Buitkus, Marius
    Zagrabskaite, Ruta
    Pautienius, Arnoldas
    Razukevicius, Dainius
    Jonaitis, Laimas Virginijus
    Kiudelis, Gediminas
    Skieceviciene, Jurgita
    Vaiciuniene, Ruta
    Stankuviene, Asta
    Bumblyte, Inga Arune
    Kupcinskas, Juozas
    Stankevicius, Arunas
    [J]. VIRUSES-BASEL, 2021, 13 (04):