Impact of nanotechnology on the oral delivery of phyto-bioactive compounds

被引:28
作者
Nsairat, Hamdi [1 ]
Lafi, Zainab [1 ]
Al-Sulaibi, Mazen [1 ]
Gharaibeh, Lobna [1 ]
Alshaer, Walhan [2 ]
机构
[1] Al Ahliyya Amman Univ, Fac Pharm, Pharmacol & Diagnost Res Ctr, Amman 19328, Jordan
[2] Univ Jordan, Cell Therapy Ctr, Amman 11942, Jordan
关键词
Phyto-bioactive compounds; Nutraceutical; Bioavailability; Nanoencapsulation; Biostability; Biodegradability; Oral delivery; SOLID LIPID NANOPARTICLES; BIODEGRADABLE POLYMERIC MATERIALS; CO-GLYCOLIC ACID; SEE VOL. 102; DRUG-DELIVERY; IN-VIVO; CHITOSAN NANOPARTICLES; CONTROLLED-RELEASE; CELLULAR UPTAKE; LIPOSOMAL FORMULATIONS;
D O I
10.1016/j.foodchem.2023.136438
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Nanotechnology is an advanced field that has remarkable nutraceutical and food applications. Phyto-bioactive compounds (PBCs) play critical roles in promoting health and disease treatment. However, PBCs generally encounter several limitations that delay their widespread application. For example, most PBCs have low aqueous solubility, poor biostability, poor bioavailability, and a lack of target specificity. Moreover, the high concentrations of effective PBC doses also limit their application. As a result, encapsulating PBCs into an appropriate nanocarrier may increase their solubility and biostability and protect them from premature degradation. Moreover, nanoencapsulation could improve absorption and prolong circulation with a high opportunity for targeted delivery that may decrease unwanted toxicity. This review addresses the main parameters, variables, and barriers that control and affect oral PBC delivery. Moreover, this review discusses the potential role of biocompatible and biodegradable nanocarriers in improving the water solubility, chemical stability, bioavailability, and specificity/selectivity of PBCs.
引用
收藏
页数:18
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