Beyond the DNA binding domain: How do intrinsically disordered regions within transcription factors impact DNA binding specificity?

被引：0
|
作者：
Palumbo, Rosalia [1 ]
Cunningham, Caylee [1 ]
Frye, Caleb J. [1 ]
Mihailescu, Mihaela-Rita [1 ]
机构：
[1] Duquesne Univ, Dept Chem & Biochem, Pittsburgh, PA USA
来源：
BIOPHYSICAL JOURNAL | 2023年 / 122卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
1059-Pos
引用
收藏
页码：217A / 217A
页数：1
相关论文
共 50 条
  • [1] The Conformational Landscape of an Intrinsically Disordered DNA-Binding Domain of a Transcription Regulator
    Naganathan, Athi N.
    Orozco, Modesto
    JOURNAL OF PHYSICAL CHEMISTRY B, 2013, 117 (44): : 13842 - 13850
  • [2] Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity
    Brodsky, Sagie
    Jana, Tamar
    Mittelman, Karin
    Chapal, Michal
    Kumar, Divya Krishna
    Carmi, Miri
    Barkai, Naama
    MOLECULAR CELL, 2020, 79 (03) : 459 - U18
  • [3] Complementary strategies for directing in vivo transcription factor binding through DNA binding domains and intrinsically disordered regions
    Kumar, Divya Krishna
    Jonas, Felix
    Jana, Tamar
    Brodsky, Sagie
    Carmi, Miri
    Barkai, Naama
    MOLECULAR CELL, 2023, 83 (09) : 1462 - +
  • [4] Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors
    Hosoya, Yusuke
    Nojo, Wataru
    Kii, Isao
    Suzuki, Takanori
    Imanishi, Miki
    Ohkanda, Junko
    CHEMICAL COMMUNICATIONS, 2020, 56 (76) : 11203 - 11206
  • [5] Order through disorder: The role of intrinsically disordered regions in transcription factor binding specificity
    Brodsky, Sagie
    Jana, Tamar
    Barkai, Naama
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2021, 71 : 110 - 115
  • [6] Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping
    Medina, Exequiel
    Villalobos, Pablo
    Hamilton, George L.
    Komives, Elizabeth A.
    Sanabria, Hugo
    Ramirez-Sarmiento, Cesar A.
    Babul, Jorge
    JOURNAL OF MOLECULAR BIOLOGY, 2020, 432 (19) : 5411 - 5429
  • [7] Intrinsically Disordered Regions in the Transcription Factor MYC:MAX Modulate DNA Binding via Intramolecular Interactions
    Schutz, Stefan
    Bergsdorf, Christian
    Hanni-Holzinger, Sandra
    Lingel, Andreas
    Renatus, Martin
    Gossert, Alvar D.
    Jahnke, Wolfgang
    BIOCHEMISTRY, 2024, 63 (04) : 498 - 511
  • [8] Determinants of DNA-binding specificity of ETS-domain transcription factors
    Shore, P
    Whitmarsh, AJ
    Bhaskaran, R
    Davis, RJ
    Waltho, JP
    Sharrocks, AD
    MOLECULAR AND CELLULAR BIOLOGY, 1996, 16 (07) : 3338 - 3349
  • [9] An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NFκB p50/RelA
    Baughman, Hannah E. R.
    Narang, Dominic
    Chen, Wei
    Suarez, Amalia C. Villagran
    Lee, Joan
    Bachochin, Maxwell J.
    Gunther, Tristan R.
    Wolynes, Peter G.
    Komives, Elizabeth A.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 298 (09)
  • [10] Walking the DNA Methylation Tightrope: The Involvement of Intrinsically Disordered Regions of Transcription Factors
    Bilinovich, Stephanie M.
    Pan, Hai
    Kaur, Parminder
    Wang, Hong
    Williams, David C., Jr.
    BIOPHYSICAL JOURNAL, 2017, 112 (03) : 207A - 207A
12345