The role of frailty in advanced HF and cardiac transplantation

被引：4

作者：

Bart, Nicole K. K. ^{[1
,2
,3
,4
]}

Powell, Alice ^{[5
,6
]}

Macdonald, Peter S. S. ^{[1
,3
,4
]}

机构：

[1] St Vincents Hosp, Heart Transplant Program, Sydney, NSW, Australia

[2] Univ Notre Dame, Sch Med, Sydney, NSW, Australia

[3] Univ New South Wales, Sch Med, Sydney, NSW, Australia

[4] Victor Chang Cardiac Res Inst, Infiltrat Cardiomyopathy Lab, Sydney, NSW, Australia

[5] Univ New South Wales, Fac Med, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia

[6] Macquarie Univ Hosp, Dept Neurol, Sydney, NSW, Australia

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2023年 / 10卷

关键词：

frailty; heart failure; cardiac disease; ageing; superAging; transplantation; robustness; CHRONIC HEART-FAILURE; OLDER-ADULTS; EXERCISE PRESCRIPTION; CLINICAL-PRACTICE; OXIDATIVE STRESS; PREVALENCE; MORTALITY; INFLAMMATION; DEFINITION; SARCOPENIA;

D O I：

10.3389/fcvm.2023.1082371

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Frailty is a complex, multi-system condition often associated with multimorbidity. It has become an important prognostic maker across a range of conditions and is particularly relevant in patients with cardiovascular disease. Frailty encompasses a range of domains including, physical, psychological, and social. There are currently a range of validated tools available to measure frailty. It is an especially important measurement in advanced HF, because frailty occurs in up to 50% of HF patients and is potentially reversible with therapies such as mechanical circulatory support and transplantation. Moreover, frailty is dynamic, and therefore serial measurements are important. This review delves into the measurement of frailty, mechanisms, and its role in different cardiovascular cohorts. Understanding frailty will help determine patients that will benefit from therapies, as well as prognosticate outcomes.

引用

页数：8

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