Recommendations for reviewing the effectiveness and documentation of the course of mepolizumab in chronic rhinosinusitis with nasal polyps (CRSwNP) in the German healthcare system

被引：3

作者：

Klimek, L. ^{[1
,30
]}

Foerster-Ruhrmann, U. ^{[2
]}

Olze, H. ^{[2
]}

Beule, A. G. ^{[3
,4
]}

Chaker, A. M. ^{[5
,6
]}

Hagemann, J. ^{[7
]}

Huppertz, T. ^{[7
]}

Hoffmann, T. K. ^{[8
]}

Dazert, S. ^{[9
]}

Deitmer, T. ^{[10
]}

Strieth, S. ^{[11
]}

Wrede, H.

Schlenter, W. ^{[12
]}

Welkoborsky, H. J. ^{[13
]}

Wollenberg, B. ^{[5
]}

Becker, S. ^{[14
]}

Baerhold, F. ^{[14
]}

Klimek, F. ^{[1
]}

Casper, I. ^{[1
]}

Zuberbier, J. ^{[2
]}

Rudack, C. ^{[3
]}

Cuevas, M. ^{[15
]}

Hintschich, C. A. ^{[16
]}

Guntinas-Lichius, O. ^{[17
]}

Stoever, T. ^{[18
]}

Bergmann, C. ^{[19
]}

Werminghaus, P. ^{[20
]}

Pfaar, O. ^{[21
]}

Gosepath, J. ^{[22
]}

Groeger, M. ^{[23
]}

Beutner, C. ^{[24
]}

Laudien, M. ^{[25
]}

Weber, R. K. ^{[26
]}

Hildenbrand, T. ^{[27
]}

Hoffmann, A. S. ^{[28
]}

Bachert, C. ^{[29
]}

机构：

[1] Zent Rhinol & Allergol, Wiesbaden, Germany

[2] Charite Univ Med Berlin, Klin Hals Nasen & Ohrenheilkunde, Berlin, Germany

[3] Univ klinikum Munster, Klin Hals Nasen & Ohrenheilkunde, Munich, Germany

[4] Univ Med Greifswald, Klin Hals Nasen Ohrenheilkunde Kopf & Halschirurg, Greifswald, Germany

[5] Tech Univ Munich, TUM Sch Med, Klinikum Rechts Isar, Klin fur Hals Nasen & Ohrenheilkunde, Munich, Germany

[6] Tech Univ Munich, TUM, Zent Allergie & Umwelt ZAUM, Klinikum Rechts Isar,Sch Med, Munich, Germany

[7] Univ Med Mainz, Klin Hals Nasen & Ohrenheilkunde, Mainz, Germany

[8] Univ klinikum Ulm, Klin Hals Nasen & Ohrenheilkunde, Ulm, Germany

[9] Ruhr Univ Bochum, St Elisabeth Hosp, Klin Hals Nasen Ohrenheilkunde Kopf & Halschirurgi, Bochum, Germany

[10] Deutsch Gesell Hals Nasen & Ohrenheilkunde, Kopf & Halschirurg, Bonn, Germany

[11] Univ Klinikum Bonn, Klin & Poliklin Hals Nasen Ohrenheilkunde, Bonn, Germany

[12] Arzteverband Deutsch Allergologen, Wiesbaden, Germany

[13] Klinikum Hannover, Klin Hals Nasen & Ohrenheilkunde, Hannover, Germany

[14] Univ Klin Tubingen, Klin Hals Nasen & Ohrenheilkunde, Tubingen, Germany

[15] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Klin & Poliklin HNO Heilkunde, Dresden, Germany

[16] Univ Klinikum Regensburg, Klin & Poliklin Hals Nasen Ohrenheilkunde, Regensburg, Germany

[17] Univ klinikum Jena, Klin Hals Nasen & Ohrenheilkunde, Jena, Germany

[18] Univ Hals Nasen Ohrenklinik Frankfurt, Frankfurt, Germany

[19] Klin RKM 740, Praxis Hals Nasen Ohrenheilkunde, Dusseldorf, Germany

[20] Praxis Hals Nasen Ohrenheilkunde & Allergol, Dusseldorf, Germany

[21] Philipps Univ Marburg, Univ Klinikum Giessen & Marburg GmbH, Klini Hals Nasen & Ohrenheilkunde, Marburg, Germany

[22] HSK Wiesbaden, Klin Hals Nasen & Ohrenheilkunde, Wiesbaden, Germany

[23] Univ Klinikum LMU Munchen, Klin & Poliklin Hals Nasen Ohrenheilkunde, Munich, Germany

[24] Univ Med Gottingen, Allergiezentrum Sudniedersachsen, Klin Dermatol Venerol & Allergol, Gottingen, Germany

[25] Univ Klinikum Kiel, Klin Hals Nasen & Ohrenheilkunde, Kiel, Germany

[26] Stadt Klinikum Karlsruhe, Klin Hals Nasen & Ohrenheilkunde, Karlsruhe, Germany

[27] Univ Klinikum Freiburg, Klin Hals Nasen & Ohrenheilkunde, Freiburg, Germany

[28] Univ Klinikum Hamburg Eppendorf, Klin Hals Nasen & Ohrenheilkunde, Hamburg, Germany

[29] Univ Klinikum Gent, Klin Hals Nasen & Ohrenheilkunde, Ghent, Belgium

[30] Zent Rhinol & Allergol Wiesbaden, Quellen 10, D-65183 Wiesbaden, Germany

来源：

LARYNGO-RHINO-OTOLOGIE | 2023年 / 102卷 / 02期

关键词：

chronic rhinosinusitis; CRSwNP; biologicals; eosinophilic inflammation; mepolizumab; ENDOSCOPIC SINUS SURGERY; ODOR IDENTIFICATION; POSITION PAPER; NORMATIVE DATA; ASTHMA; PREVALENCE; PLACEBO; SAFETY; DISCRIMINATION; RECURRENCE;

D O I：

10.1055/a-2003-4730

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes of the nose and sinuses. Eosinophilic inflammation is described as a common endotype. The anti-IL5 antibody mepolizumab was approved in November 2021 as an add-on therapy to intranasal glucocorticosteroids for the treatment of adults with severe chronic rhinosinusitis with nasal polyps when systemic glucocorticosteroids or surgery do not provide adequate disease control. While national and international recommendations exist for the use of mepolizumab in CRSwNP, it has not yet been adequately specified how this therapy is to be monitored, what follow-up documentation is necessary, and when it should be terminated if necessary.Methods A literature search was performed to analyze previous data on the treatment of CRSwNP with mepolizumab and to determine the available evidence by searching Medline, Pubmed, the national and international trial and guideline registries and the Cochrane Library. Human studies published in the period up to and including 10/2022 were considered.Results Based on the international literature and previous experience by an expert panel, recommendations for follow-up, adherence to therapy intervals and possible therapy breaks, as well as termination of therapy when using mepolizumab for the indication CRSwNP in the German health care system are given on the basis of a documentation sheet.Conclusions Understanding the immunological basis of CRSwNP opens up new non-surgical therapeutic approaches with biologics for patients with severe, uncontrolled courses. Here, we provide recommendations for follow-up, adherence to therapy intervals, possible therapy pauses, or discontinuation of therapy when mepolizumab is used as add-on therapy with intranasal glucocorticosteroids to treat adult patients with severe CRSwNP that cannot be adequately controlled with systemic glucocorticosteroids and/or surgical intervention.

引用

页码：89 / 99

页数：11

共 50 条

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