Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns

被引:1
作者
Wang, Jizhuang [1 ]
Lu, Chenghao [1 ]
Liu, Xinying [1 ]
Zhang, Gai [1 ]
Zhang, Jie [1 ]
Gao, Min [1 ]
Liu, Dan [1 ]
Zhang, Xiong [1 ]
Liu, Yan [1 ]
机构
[1] Shanghai Jiaotong Univ Sch Med, Shanghai Ruijin Hosp, Dept Burn, Shanghai, Peoples R China
来源
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
基金
中国国家自然科学基金;
关键词
histamine; cetirizine; promethazine; severe burns; catecholamine; organ injury; MIDAZOLAM; SEDATION; FENTANYL; PLACEBO;
D O I
10.3389/fendo.2023.1068925
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Severe burns induce a catecholamine surge, causing severe damage to the organism and raising the possibility of multisystem organ failure. Few strategies are generally acceptable to reduce catecholamine surge and organ injury post-burn. We have previously shown that histamine can amplify the catecholamine surge. In addition, promethazine, a first-generation histamine H1 receptor antagonist, alleviates catecholamine surge and organ injury after severe burns in rats. However, evidence is lacking on whether promethazine benefits patients after severe burns. Currently, sedation and analgesia (such as midazolam and fentanyl) are commonly required for patients after severe burns. It remains unclear if patients after severe burns derive clinical benefit from histamine H1 receptor antagonists combined with sedation and analgesia. This study investigates the therapeutic effect of promethazine on patients after severe burns. Moreover, we test the therapeutic effect of cetirizine, a second-generation histamine H1 receptor antagonist, combined with sedation and analgesia in rats after severe burns. We find that promethazine-pethidine treatment shows a tendency for a lower level of total bilirubin than midazolam-fentanyl in patients 7-day after severe burn. Our study confirms that cetirizine combined with midazolam and fentanyl reduces catecholamine surge and liver and lung damage after severe burns in rats; the effects are better than midazolam and fentanyl treatment. In summary, for the first time, we suggest that histamine H1 receptor antagonist has the potential clinical value of reducing liver injury in patients after severe burns. In addition, we reveal that cetirizine combined with midazolam and fentanyl may be an ideal strategy for treating severe burns.
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页数:9
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共 27 条
  • [1] Catecholamines Induce Endoplasmic Reticulum Stress Via Both Alpha and Beta Receptors
    Abdullahi, Abdikarim
    Wang, Vivian
    Auger, Christopher
    Patsouris, David
    Amini-Nik, Saeid
    Jeschke, Marc G.
    [J]. SHOCK, 2020, 53 (04): : 476 - 484
  • [2] Agrawal Vikas K, 2022, J Assoc Physicians India, V70, P11, DOI 10.5005/japi-11001-0026
  • [3] The Role of Cetirizine in the Changing Landscape of IV Antihistamines: A Narrative Review
    Blaiss, Michael S.
    Bernstein, Jonathan A.
    Kessler, Adam
    Pines, Jesse M.
    Camargo, Carlos A., Jr.
    Fulgham, Paula
    Haumschild, Ryan
    Rupp, Kristin
    Tyler, Timothy
    Moellman, Joseph
    [J]. ADVANCES IN THERAPY, 2022, 39 (01) : 178 - 192
  • [4] The Notch pathway attenuates burn-induced acute lung injury in rats by repressing reactive oxygen species
    Cai, Weixia
    Shen, Kuo
    Ji, Peng
    Jia, Yanhui
    Han, Shichao
    Zhang, Wanfu
    Hu, Xiaolong
    Yang, Xuekang
    Han, Juntao
    Hu, Dahai
    [J]. BURNS & TRAUMA, 2022, 10
  • [5] Catecholamines in the regulation of angiogenesis in cutaneous wound healing
    Chakroborty, Debanjan
    Goswami, Sandeep
    Basu, Sujit
    Sarkar, Chandrani
    [J]. FASEB JOURNAL, 2020, 34 (11) : 14093 - 14102
  • [6] Update on Pruritic Mechanisms of Hypertrophic Scars in Postburn Patients: The Potential Role of Opioids and Their Receptors
    Cheng, Biao
    Liu, Hong-Wei
    Fu, Xiao-Bing
    [J]. JOURNAL OF BURN CARE & RESEARCH, 2011, 32 (04) : E118 - E125
  • [7] Feasibility and impact of the implementation of a clinical scale-based sedation-analgesia protocol in severe burn patients undergoing mechanical ventilation. A before-after bi-center study
    Cinotti, Raphael
    Besnard, Noemie
    Desmedt, Luc
    Le Floch, Ronan
    Perrot, Pierre
    Bekara, Farid
    Klouche, Kada
    Larcher, Romaric
    Mahe, Pierre Joachim
    Frasca, Denis
    Asehnoune, Karim
    Jung, Boris
    Roquilly, Antoine
    [J]. BURNS, 2020, 46 (06) : 1310 - 1317
  • [8] Long-term effects of pulsed high-intensity laser therapy in the treatment of post-burn pruritus: a double-blind, placebo-controlled, randomized study
    Ebid, Anwar Abdelgayed
    Ibrahim, Abeer Ramadan
    Omar, Mohammed Taher
    Abd El Baky, Amal Mohamed
    [J]. LASERS IN MEDICAL SCIENCE, 2017, 32 (03) : 693 - 701
  • [9] Levocetirizine Pretreatment Mitigates Lipopolysaccharide-Induced Lung Inflammation in Rats
    Fahmi, Alaa N. A.
    Shehatou, George S. G.
    Salem, Hatem A.
    [J]. BIOMED RESEARCH INTERNATIONAL, 2018, 2018
  • [10] A study comparing the effect of premedication with intravenous midazolam or dexmedetomidine on ketamine-fentanyl sedoanalgesia in burn patients: A randomized clinical trial
    Gencer, Muzaffer
    Sezen, Ozlem
    [J]. BURNS, 2021, 47 (01) : 101 - 109