Vaccine Effectiveness Against 12-Month Incident and Persistent Anal Human Papillomavirus Infection Among Gay, Bisexual, and Other Men Who Have Sex With Men

被引:6
作者
Chambers, Catharine [1 ,2 ]
Deeks, Shelley L. [1 ,3 ,4 ]
Sutradhar, Rinku [1 ,5 ]
Cox, Joseph [6 ,7 ]
de Pokomandy, Alexandra [8 ]
Grennan, Troy [9 ,10 ]
Hart, Trevor A. [1 ,11 ]
Lambert, Gilles [7 ]
Moore, David M. [12 ]
Grace, Daniel [1 ]
Grewal, Ramandip [2 ]
Jollimore, Jody [13 ]
Lachowsky, Nathan [14 ]
Nisenbaum, Rosane [2 ]
Ogilvie, Gina [10 ]
Sauvageau, Chantal [15 ]
Tan, Darrell H. S. [2 ]
Coutlee, Francois [16 ,17 ]
Burchell, Ann N. [1 ,2 ]
机构
[1] Univ Toronto, Dalla Lana Sch Publ Hlth, Dept Family & Community Med, Toronto, ON, Canada
[2] Unity Hlth Toronto, Toronto, ON, Canada
[3] Govt Nova Scotia, Halifax, NS, Canada
[4] Dalhousie Univ, Dept Community Hlth & Epidemiol, Halifax, NS, Canada
[5] Inst Clin Evaluat Sci ICES, Toronto, ON, Canada
[6] McGill Univ Hlth Ctr, Res Inst, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada
[7] Direct Regionale Sante Publ Montreal, Montreal, PQ, Canada
[8] McGill Univ Hlth Ctr, Res Inst, Dept Family Med, Montreal, PQ, Canada
[9] British Columbia Ctr Dis Control, Vancouver, BC, Canada
[10] Univ British Columbia, Sch Populat & Publ Hlth, Ctr Urban Hlth Solut, Unity Hlth Toronto, 30 Bond St, Vancouver, BC M5B 1W8, Canada
[11] Toronto Metropolitan Univ, Dept Psychol, Toronto, ON, Canada
[12] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada
[13] Community Based Res Ctr, Vancouver, BC, Canada
[14] Univ Victoria, Sch Publ Hlth & Social Policy, Victoria, BC, Canada
[15] Inst Natl Sante Publ Quebec, Quebec City, PQ, Canada
[16] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada
[17] Univ Montreal, Ctr Rech Ctr Hosp, Montreal, PQ, Canada
关键词
human papillomavirus; incidence; men who have sex with men; persistent infection; vaccination; vaccine effectiveness; ORAL HUMAN-PAPILLOMAVIRUS; HIV-INFECTION; HPV VACCINE; END-POINTS; PREVALENCE; CLEARANCE; SITE;
D O I
10.1093/infdis/jiad005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background Real-world evidence of human papillomavirus (HPV) vaccine effectiveness (VE) against longitudinal outcomes is lacking among gay, bisexual, and other men who have sex with men (GBM). We compared 12-month incidence and persistence of anal HPV infection between vaccinated and unvaccinated GBM. Methods We recruited GBM aged 16-30 years in Montreal, Toronto, and Vancouver, Canada, from 2017 to 2019. Participants were followed over a median of 12 months (interquartile range, 12-13 months). Participants self-reported HPV vaccination and self-collected anal specimens for HPV DNA testing. We calculated prevalence ratios (PR) for 12-month cumulative incidence and persistence with >= 1 quadrivalent vaccine type (HPV 6/11/16/18) between vaccinated (>= 1 dose at baseline) and unvaccinated participants using a propensity score-weighted, modified Poisson regression. Results Among 248 participants, 109 (44.0%) were vaccinated at baseline, of whom 62.6% received 3 doses. PRs for HPV 6/11/16/18 were 0.56 (95% confidence interval [CI], .24-1.31) for cumulative incidence and 0.53 (95% CI, .25-1.14) for persistence. PRs were 0.23 (95% CI, .05-1.03) and 0.08 (95% CI, .01-.59) for incidence and persistence, respectively, among participants who received their first dose at age <= 23 years and 0.15 (95% CI, .03-.68) and 0.12 (95% CI, .03-.54) among participants who were sexually active for <= 5 years before vaccination. Conclusions Findings support national recommendations for HPV vaccination at younger ages or soon after sexual debut. Among sexually active men who have sex with men aged 16-30 years, human papillomavirus (HPV) vaccine was significantly protective against 12-month anal HPV cumulative incidence and persistence when vaccination was initiated at younger ages or soon after sexual debut.
引用
收藏
页码:89 / 100
页数:12
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