Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C-C Bond Scission

被引：46

作者：

Lv, Xin-Yang ^{[1
,2
]}

Abrams, Roman ^{[1
]}

Martin, Ruben ^{[1
,3
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain

[2] Univ Rovira i Virgili, Dept Quim Analit & Quim Organ, C-Marcel li Domingo, 1, Tarragona 43007, Spain

[3] Passeig Lluis Co, Catalan Inst Res & Adv Studies ICREA, 23, Barcelona 08010, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 08期

基金：

欧洲研究理事会;

关键词：

Amination; C-C Functionalization; Copper; Ketones; Proaromaticity; SECONDARY ALKYL-HALIDES; CARBON-CARBON BONDS; ACTIVATION; AMINES; AMIDATION; IMIDATION; COUPLINGS; OXIDATION;

D O I：

10.1002/anie.202217386

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we describe the development of a copper-catalyzed C(sp(3))-amination of proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the intermediacy of open-shell species arising from homolytic C-C bond-cleavage driven by aromatization. The protocol is characterized by its operational simplicity and generality, including chemical diversification of advanced intermediates.

引用

页数：6

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