Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C-C Bond Scission

被引：38
作者：
Lv, Xin-Yang [1 ,2 ]
Abrams, Roman [1 ]
Martin, Ruben [1 ,3 ]
机构：
[1] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain
[2] Univ Rovira i Virgili, Dept Quim Analit & Quim Organ, C-Marcel li Domingo, 1, Tarragona 43007, Spain
[3] Passeig Lluis Co, Catalan Inst Res & Adv Studies ICREA, 23, Barcelona 08010, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 08期
基金：
欧洲研究理事会;
关键词：
Amination; C-C Functionalization; Copper; Ketones; Proaromaticity; SECONDARY ALKYL-HALIDES; CARBON-CARBON BONDS; ACTIVATION; AMINES; AMIDATION; IMIDATION; COUPLINGS; OXIDATION;
D O I：
10.1002/anie.202217386
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we describe the development of a copper-catalyzed C(sp(3))-amination of proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the intermediacy of open-shell species arising from homolytic C-C bond-cleavage driven by aromatization. The protocol is characterized by its operational simplicity and generality, including chemical diversification of advanced intermediates.
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页数：6
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